Tumor-derived exosomes in the regulation of macrophage polarization

• Published in: Inflammation research Vol. 69; no. 5; pp. 435 - 451
• Main Authors: Baig, Mirza S., Roy, Anjali, Rajpoot, Sajjan, Liu, Dongfang, Savai, Rajkumar, Banerjee, Sreeparna, Kawada, Manabu, Faisal, Syed M., Saluja, Rohit, Saqib, Uzma, Ohishi, Tomokazu, Wary, Kishore K.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.05.2020; Springer Nature B.V
• Subjects: Allergology; Antibodies; Biomedical and Life Sciences; Biomedicine; Breast cancer; Cell activation; Colorectal cancer; Colorectal carcinoma; Crosstalk; Cytokines; Cytotoxicity; Dendritic cells; Dermatology; Exosomes; Glioblastoma; Growth factors; Hepatocellular carcinoma; Immunology; Inflammation; Intracellular signalling; Lipids; Liver cancer; Lung cancer; Lung carcinoma; Lymphocytes; Lymphocytes B; Macrophages; Mast cells; mRNA; Neurology; Oral cancer; Ovarian cancer; Pancreas; Pancreatic cancer; Pharmacology/Toxicology; Phenotypes; Platelets; Polarization; Prostate cancer; Reticulocytes; Review; Reviews; Rheumatology; Signal transduction; Signaling; Squamous cell carcinoma; Toxicity; Tumor cells; Tumors; Wireless communications; M2 macrophages; Tumor; Inflammatory response; Exosomes; M1 macrophages

Background This review focuses on exosomes derived from various cancer cells. The review discusses the possibility of differentiating macrophages in alternatively activated anti-inflammatory pro-tumorigenic M2 macrophage phenotypes and classically activated pro-inflammatory, anti-tumorigenic M1 macr...