Acute Doxorubicin Cardiotoxicity

• Published in: The New England journal of medicine Vol. 352; no. 23; pp. 2456 - 2457
• Main Authors: Hayek, Emil R, Speakman, Eric, Rehmus, Esther
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 09.06.2005
• Subjects: Aged; Antibiotics, Antineoplastic - adverse effects; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Carcinoid Tumor - drug therapy; Chemoembolization, Therapeutic - adverse effects; Doxorubicin - adverse effects; Female; Humans; Liver Neoplasms - drug therapy; Myocardial Stunning - chemically induced; Pulmonary Edema - chemically induced; Ventricular Dysfunction, Left - chemically induced

To the Editor: A previously healthy 78-year-old woman presented with facial flushing, palpitations, diarrhea, and generalized weakness. The serum serotonin level was markedly elevated (2233 ng per milliliter; normal, <180), as was urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) (118.7 mg...