Acute Doxorubicin Cardiotoxicity
To the Editor: A previously healthy 78-year-old woman presented with facial flushing, palpitations, diarrhea, and generalized weakness. The serum serotonin level was markedly elevated (2233 ng per milliliter; normal, <180), as was urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) (118.7 mg...
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| Published in | The New England journal of medicine Vol. 352; no. 23; pp. 2456 - 2457 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Massachusetts Medical Society
09.06.2005
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| Subjects | |
| Online Access | Get full text |
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| Abstract | To the Editor:
A previously healthy 78-year-old woman presented with facial flushing, palpitations, diarrhea, and generalized weakness. The serum serotonin level was markedly elevated (2233 ng per milliliter; normal, <180), as was urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) (118.7 mg per 24 hours; normal, <6.0), and a computed tomographic (CT) scan revealed a small-bowel mass, 3 cm by 2.5 cm, with multiple hepatic lesions. Fine-needle liver biopsy demonstrated cytokeratin- and chromogranin-staining cells, which are characteristic of carcinoid tumor. Despite monthly injections of octreotide, the patient's flushing persisted, and a CT scan showed enlargement of both small-bowel and liver masses. She . . . |
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| AbstractList | To the Editor:
A previously healthy 78-year-old woman presented with facial flushing, palpitations, diarrhea, and generalized weakness. The serum serotonin level was markedly elevated (2233 ng per milliliter; normal, <180), as was urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) (118.7 mg per 24 hours; normal, <6.0), and a computed tomographic (CT) scan revealed a small-bowel mass, 3 cm by 2.5 cm, with multiple hepatic lesions. Fine-needle liver biopsy demonstrated cytokeratin- and chromogranin-staining cells, which are characteristic of carcinoid tumor. Despite monthly injections of octreotide, the patient's flushing persisted, and a CT scan showed enlargement of both small-bowel and liver masses. She . . . Acute pulmonary edema necessitating mechanical ventilation developed 30 hours after chemoembolization. |
| Author | Speakman, Eric Rehmus, Esther Hayek, Emil R |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15944435$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.7326/0003-4819-125-1-199607010-00008 10.1056/NEJM199809243391307 10.1007/s00330-002-1558-0 |
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| Snippet | To the Editor:
A previously healthy 78-year-old woman presented with facial flushing, palpitations, diarrhea, and generalized weakness. The serum serotonin... Acute pulmonary edema necessitating mechanical ventilation developed 30 hours after chemoembolization. |
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| SubjectTerms | Aged Antibiotics, Antineoplastic - adverse effects Antineoplastic Combined Chemotherapy Protocols - administration & dosage Carcinoid Tumor - drug therapy Chemoembolization, Therapeutic - adverse effects Doxorubicin - adverse effects Female Humans Liver Neoplasms - drug therapy Myocardial Stunning - chemically induced Pulmonary Edema - chemically induced Ventricular Dysfunction, Left - chemically induced |
| Title | Acute Doxorubicin Cardiotoxicity |
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