Unraveling the rationale and conducting a comprehensive assessment of KD025 (Belumosudil) as a candidate drug for inhibiting adipogenic differentiation—a systematic review - Barbalho, Sandra Maria; de Alvares Goulart, Ricardo; Minniti, Giulia; Bechara, Marcelo Dib; de Castro, Marcela Vialogo Marques; Dias, Jefferson Aparecido; Laurindo, Lucas Fornari (Naunyn-Schmiedeberg's archives of pharmacology, 2024)
Keywords: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology; Adipocytes - drug effects; Adipocytes - metabolism; Adipogenesis; Adipogenesis - drug effects; Animals; Biomedical and Life Sciences; Biomedicine; CCAAT/enhancer-binding protein; Cell culture; Cell Differentiation - drug effects; Clinical trials; Fatty acid-binding protein; Fibronectin; Heterocyclic Compounds, 4 or More Rings; Humans; Kinases; Mice; Neurosciences; Peroxisome proliferator-activated receptors; Pharmacology/Toxicology; Protein Kinase Inhibitors - pharmacology; Proteins; Review; Reviews; rho-Associated Kinases - antagonists & inhibitors; rho-Associated Kinases - metabolism; Sterol regulatory element-binding protein; Systematic review; Therapeutic applications; Casein kinase; KD025; Adipocyte differentiation; ROCK2; Rho-associated kinase; Belumosudil