YAP/TAZ-TEAD is a novel transcriptional regulator of genes encoding steroidogenic enzymes in rat granulosa cells and KGN cells

• Published in: Molecular and cellular endocrinology Vol. 559; p. 111808
• Main Authors: Mizutani, Tetsuya, Orisaka, Makoto, Kawabe, Shinya, Morichika, Ririko, Uesaka, Miki, Yoshida, Yoshio
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.01.2023
• Subjects: Animals; Cyclic AMP; Female; Follicle Stimulating Hormone - metabolism; Gene Expression Regulation; Granulosa cell; Granulosa Cells - metabolism; Rats; Steroidogenic enzymes; TEA domain Transcription factor; Transcription Factors - genetics; Transcription Factors - metabolism; Transcriptional coactivator with PDZ-Binding motif; YAP-Signaling Proteins; Yes-associated protein; Yes-associated protein; Cyclic AMP; TEA domain Transcription factor; Granulosa cell; Transcriptional coactivator with PDZ-Binding motif; Steroidogenic enzymes

Steroidogenesis in ovarian granulosa cells is regulated by the follicle-stimulating hormone (FSH) via transcriptional regulation of its related genes. We herein showed the involvement of the Hippo pathway in this regulation. In KGN granulosa cell, repression of YAP/TAZ activity induced the expressio...