Monocytes of newly diagnosed juvenile DM1 patients are prone to differentiate into regulatory IL-10+ M2 macrophages

• Published in: Immunologic research Vol. 67; no. 1; pp. 58 - 69
• Main Authors: Juhas, Ulana, Ryba-Stanisławowska, Monika, Brandt-Varma, Agnieszka, Myśliwiec, Małgorzata, Myśliwska, Jolanta
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2019; Springer Nature B.V
• Subjects: Adolescent; Allergology; Biomedical and Life Sciences; Biomedicine; CD14 antigen; CD86 antigen; Cell Differentiation; Cell-mediated immunity; Cells, Cultured; Child; Children; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - immunology; Female; Humans; Immunology; Inflammation; Interferon; Interferon regulatory factor 4; Interferon Regulatory Factors - metabolism; Interleukin 10; Interleukin 4; Interleukin-10 - metabolism; Interleukin-4 - metabolism; Internal Medicine; Intracellular; Lectins, C-Type - metabolism; Lipopolysaccharide Receptors; Macrophages; Macrophages - immunology; Male; Mannose-Binding Lectins - metabolism; Medicine/Public Health; Monocytes; Original Article; Phenotypes; Receptors, Cell Surface - metabolism; Th2 Cells - immunology; Transcription factors; Tumor necrosis factor-α; M2 macrophages; IRF5; Type 1 diabetes; IRF4

Alternatively activated macrophages (M2) exert anti-inflammatory effects and are crucial for keeping balance between protective and destructive cell-mediated immunity in healing phase of inflammation. Two members of the interferon regulatory factors family, IRF5 and IRF4, are known to promote M1 or...