Neutrophils Enhance Cutaneous Vascular Dilation and Permeability to Aggravate Psoriasis by Releasing Matrix Metallopeptidase 9

• Published in: Journal of investigative dermatology Vol. 141; no. 4; pp. 787 - 799
• Main Authors: Chen, Jiaoling, Zhu, Zhenlai, Li, Qingyang, Lin, Yiting, Dang, Erle, Meng, Hua, Sha, Nanxi, Bai, Hua, Wang, Gang, An, Shujie, Shao, Shuai
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2021
• Subjects: MMP; Ca2; VEC; IMQ; HMEC-1; ERK; VE

Neutrophil infiltration and papillary vessel dilation are hallmarks of the initiation phase of psoriatic lesions. However, how neutrophils aggravate psoriasis development during transendothelial migration and the interaction between neutrophils and cutaneous vascular endothelial cells are less well-...