Blood compatibility of polyethersulfone membrane by blending a sulfated derivative of chitosan

• Published in: Carbohydrate polymers Vol. 95; no. 1; pp. 64 - 71
• Main Authors: Xue, Jimin, Zhao, Weifeng, Nie, Shengqiang, Sun, Shudong, Zhao, Changsheng
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 05.06.2013; Elsevier
• Subjects: adhesion; Adsorption; Adult; Applied sciences; Blood Coagulation; Blood compatibility; blood platelets; blood serum; bovine serum albumin; cattle; cell adhesion; Chitosan; Chitosan - chemistry; Exact sciences and technology; Exchange resins and membranes; fibrinogen; Fibrinogen - chemistry; Forms of application and semi-finished materials; Fourier transform infrared spectroscopy; Humans; Male; Membranes, Artificial; mixing; nuclear magnetic resonance spectroscopy; Platelet Adhesiveness; Polyethersulfone; Polymer industry, paints, wood; Polymers - chemistry; separation; Serum Albumin, Bovine - chemistry; solubility; solvents; Sulfones - chemistry; Sulfonic Acids - chemistry; Surface Properties; Technology of polymers; thromboplastin; Ultrafiltration; X-ray diffraction; Polyethersulfone; Blood compatibility; Chitosan; Biological properties; Blood; Chlorosulfuric acid; Wettability; Ultrafiltration; Cell adhesion; Organic sulfate; Surface properties; Partial thromboplastin time; Biocompatibility; Membrane; Polymer blends; Ethersulfone polymer; Phase reversal; Serum albumin; Experimental study; Sulfatation; Chemical modification; Platelet; Chitosan derivatives; Biofouling; Morphology; Preparation; Chemical protection; Oside polymer
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2013.02.033

► A new organosoluble sulfated derivative of chitosan was obtained by a simple method. ► The derivative of chitosan can be conveniently used to modify PES membrane. ► The blood compatibility of the modified PES membrane was improved. In this study, a novel sulfated derivative of chitosan, which could be dissolved in many common organic solvents, is conveniently synthesized for the modification of polyethersulfone (PES) membrane. Elemental analysis, FTIR, 1H NMR and X-ray diffraction diagrams (XRD) are used to demonstrate the introduction of functional groups. Owing to the solubility in organic solvents, the sulfated derivative of chitosan could be directly blended with PES in organic solvent to prepare membrane by means of a liquid–liquid phase separation technique. The modified membrane showed lower protein (bovine serum albumin (BSA) and bovine serum fibrinogen (BFG)) adsorption and suppressed platelet adhesion. Moreover, the activated partial thromboplastin time (APTT) for the modified membrane was enhanced as high as 60% compared to pure PES membrane. The lower protein adsorption, suppressed platelet adhesion and increased APTT confirmed that the blood compatibility of the modified PES membrane by the sulfated derivative of chitosan was significantly improved.