Regulating NLRP3 Inflammasome–Induced Pyroptosis via Nrf2: TBHQ Limits Hyperoxia-Induced Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia

• Published in: Inflammation Vol. 46; no. 6; pp. 2386 - 2401
• Main Authors: Wang, Minrong, Zhang, Feng, Ning, Xuemei, Wu, Chan, Zhou, Yue, Gou, Zhixian, Fan, Yang, Duan, Rongrong, Li, Zhongni, Shao, Chunyan, Lu, Liqun
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2023; Springer Nature B.V
• Subjects: Alveoli; Animals; Biomedical and Life Sciences; Biomedicine; Bronchopulmonary Dysplasia - drug therapy; Cell death; Disease Models, Animal; DNA damage; Dysplasia; Heme oxygenase (decyclizing); Humans; Hyperoxia; Hyperoxia - complications; Immunology; Infant, Newborn; Infants; Inflammasomes; Inflammasomes - metabolism; Inflammation; Internal Medicine; Lung diseases; Lung Injury - drug therapy; Lungs; Mice; Neonates; NF-E2-Related Factor 2 - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NRF2 protein; Oxidative stress; Pathology; Pharmacology/Toxicology; Premature babies; Premature birth; Pyrin protein; Pyroptosis; Reactive oxygen species; Rheumatology; Signal transduction; t-Butylhydroquinone; TBHQ; pyroptosis; NLRP3; bronchopulmonary dysplasia; Nrf2; ROS

Nuclear factor e2–related factor 2 (Nrf2) plays a key role in cellular resistance to oxidative stress injury. Oxidative stress injury, caused by Nrf2 imbalance, results in increased pyroptosis, DNA damage, and inflammatory activation, which may lead to the arrest of alveolar development and bronchop...