In-vitro antiplatelet effect of melatonin in healthy individuals and patients with type 2 diabetes mellitus

• Published in: Journal of endocrinological investigation Vol. 46; no. 12; pp. 2493 - 2500
• Main Authors: Böhm, A., Lauko, V., Dostalova, K., Balanova, I., Varga, I., Bezak, B., Jajcay, N., Moravcik, R., Lazurova, L., Slezak, P., Mojto, V., Kollarova, M., Petrikova, K., Danova, K., Zeman, M.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2023; Springer Nature B.V
• Subjects: Adenosine diphosphate; Arachidonic acid; Circadian rhythms; Diabetes; Diabetes mellitus (non-insulin dependent); Endocrinology; Internal Medicine; Medicine; Medicine & Public Health; Melatonin; Metabolic Diseases; Original Article; Platelet aggregation; Thrombin; Circadian variation; Melatonin; Platelet aggregation; Acute myocardial infarction; Diabetes mellitus

Purpose The incidence of acute myocardial infarctions (AMI) shows circadian variation typically peaking during morning hours with a decline at night. However, this variation does not occur in patients with diabetes mellitus (DM). The night’s decline of AMI may be partially explained by melatonin-rel...