Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A

• Published in: Blood Vol. 106; no. 3; pp. 913 - 921
• Main Authors: Kashiwagi, Hirokazu, Shiraga, Masamichi, Kato, Hisashi, Kamae, Tsuyoshi, Yamamoto, Naoko, Tadokoro, Seiji, Kurata, Yoshiyuki, Tomiyama, Yoshiaki, Kanakura, Yuzuru
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.08.2005; The Americain Society of Hematology
• Subjects: Actin Depolymerizing Factors; Actins - metabolism; Antigens, CD - analysis; Biological and medical sciences; Blood coagulation. Blood cells; Blood Platelets - metabolism; Blood Platelets - physiology; Cells, Cultured; Collagen - pharmacology; Fundamental and applied biological sciences. Psychology; Humans; Microfilament Proteins - metabolism; Molecular and cellular biology; P-Selectin - analysis; Platelet; Platelet Activation - drug effects; Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors; Platelet Membrane Glycoproteins - analysis; rac GTP-Binding Proteins - metabolism; rac GTP-Binding Proteins - physiology; Recombinant Fusion Proteins - pharmacology; Semaphorin-3A - chemistry; Semaphorin-3A - pharmacology; Semaphorin-3A - physiology; Tetraspanin 30; Thrombin - pharmacology; Human; Endothelial cell; Glycoprotein IIbIIIa; Regulation(control); Platelet; Integrin; Actin; Hemostasis; Platelet function; Secretory protein; Semaphorin 3A; Biological receptor

Semaphorin 3A (Sema3560) is a secreted disulfide-bound homodimeric molecule that induces growth cone collapse and repulsion of axon growth in the nervous system. Recently, it has been demonstrated that Sema3A is produced by endothelial cells and inhibits integrin function in an autocrine fashion. In...