Effect of iron overload on impaired fertility in male patients with transfusion-dependent beta-thalassemia

• Published in: Pediatric research Vol. 83; no. 3; pp. 655 - 661
• Main Authors: Chen, Mei-Jou, Peng, Steven Shinn-Forng, Lu, Meng-Yao, Yang, Yung-Li, Jou, Shiann-Tarng, Chang, Hsiu-Hao, Chen, Shee-Uan, Lin, Dong-Tsamn, Lin, Kai-Hsin
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2018; Nature Publishing Group
• Subjects: 692/699/1541; 692/699/2768/294; 692/699/317; 692/700/1421/1628; Adult; beta-Thalassemia - blood; beta-Thalassemia - complications; Blood Transfusion; Case-Control Studies; clinical-investigation; Ferritins - blood; Follicle Stimulating Hormone - metabolism; Humans; Infertility; Infertility, Male - blood; Infertility, Male - complications; Iron; Iron - analysis; Iron Overload - complications; Liver; Magnetic Resonance Imaging; Male; Males; Medicine; Medicine & Public Health; Myocardium; NMR; Nuclear magnetic resonance; Pediatric Surgery; Pediatrics; Reactive Oxygen Species - analysis; Sperm; Spermatogenesis; Spermatozoa - pathology; Testis - diagnostic imaging; Testis - pathology; Transfusion Reaction - complications; Young Adult

Background To investigate the fertility of male patients with transfusion-dependent beta-thalassemia, and to use magnetic resonance imaging (MRI) as a novel method to assess the iron overload status of testis in such patients. Methods Twenty-one male patients with transfusion-dependent beta-thalasse...