Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

• Published in: Journal of ethnopharmacology Vol. 289; no. NA; p. 115021
• Main Authors: Fu, Chen, Wu, Yifan, Liu, Shaojiao, Luo, Chaoqin, Lu, Yuqiao, Liu, Menghan, Wang, Lingfeng, Zhang, Yunling, Liu, Xuemei
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.05.2022
• Subjects: Animals; Brain Ischemia - drug therapy; Case-Control Studies; Cell Line, Tumor; Cell Survival - drug effects; cell viability; cerebral cortex; Cerebral ischemia; China; cognitive disorders; Cognitive Dysfunction - drug therapy; Cognitive impairment; dementia; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; Ferroptosis; Ferroptosis - drug effects; gene expression regulation; glutathione; heme oxygenase (biliverdin-producing); Humans; infarction; Infarction, Middle Cerebral Artery; ingredients; ischemia; Male; malondialdehyde; memory; myeloperoxidase; NADP (coenzyme); nerve tissue; Neuroprotective Agents - isolation & purification; Neuroprotective Agents - pharmacology; neuroprotective effect; NF-E2-Related Factor 2 - metabolism; Oxidative stress; pathogenesis; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-Kinase - metabolism; phospholipid-hydroperoxide glutathione peroxidase; PI3K/AKT/Nrf2; Proto-Oncogene Proteins c-akt - metabolism; Rats; Rats, Sprague-Dawley; Rehmannia - chemistry; Rehmannia glutinosa; Rehmannioside A; Signal Transduction - drug effects; SLC7A11/GPX4; stroke; superoxide dismutase; therapeutics; toxicity; China; Rehmannioside A; Oxidative stress; Cerebral ischemia; PI3K/AKT/Nrf2; Ferroptosis; SLC7A11/GPX4; Cognitive impairment

Rehmannioside A is derived from Rehmannia glutinosa Libosch, which is widely used as an important ingredient in diverse traditional Chinese medicines to treat diseases caused by “kidney deficiency” such as cerebral arteriosclerosis, aging-related stroke and dementia in China. Recent studies have pro...