Identification of a Multi-Component Formulation for Intestinal Delivery of a GLP-1/Glucagon Co-agonist Peptide

• Published in: Pharmaceutical research Vol. 39; no. 10; pp. 2555 - 2567
• Main Authors: Tran, Huyen, Patel, Phenil J., Aburub, Aktham, Sperry, Andrea, Estwick, Selina, ElSayed, Mohamed E. H., –Mannan, Amita Datta
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2022; Springer; Springer Nature B.V
• Subjects: Agonists; Bioavailability; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Citric acid; Enzymes; Glucagon; Glucagon-like peptide 1; Health aspects; Intestinal absorption; Liraglutide; Medical Law; Organic acids; Original Research Article; Peptidase; Peptides; Pharmacology/Toxicology; Pharmacy; Physicochemical properties; Proteolysis; Small intestine; Trimers; relative bioavailability; GLP-1/glucagon co-agonist peptide; peptidase inhibitor; oral peptide delivery; permeation enhancer

Purpose Oral delivery of therapeutic peptides has been challenging due to multiple physiological factors and physicochemical properties of peptides. We report a systematic approach to identify formulation compositions combining a permeation enhancer and a peptidase inhibitor that minimize proteolyti...