Anticancer effect of petroleum ether extract from Bidens pilosa L and its constituent's analysis by GC-MS

• Published in: Journal of ethnopharmacology Vol. 217; no. NA; pp. 126 - 133
• Main Authors: Shen, Yiwei, Sun, Zhouliang, Shi, Peiying, Wang, Gang, Wu, Youjia, Li, Shaoguang, Zheng, Yanjie, Huang, Liying, Lin, Liqing, Lin, Xinhua, Yao, Hong
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.05.2018
• Subjects: Acanthaceae; active ingredients; Anticancer mechanism; antineoplastic activity; antineoplastic agents; Antitumor; Bidens pilosa; Bidens pilosa L; caspase-3; China; cytotoxicity; ethanol; gas chromatography-mass spectrometry; GC-MS; human cell lines; inhibitory concentration 50; lung neoplasms; mice; neoplasm cells; oral administration; petroleum; Petroleum ether extract; protein synthesis; stigmasterol; traditional medicine; Triterpenes; triterpenoids; Western blotting; China; Bcl-2; PBS; Triterpenes; Anticancer mechanism; Bidens pilosa L; DMSO; MTT; GC-MS; FBS; Antitumor; Bax; PEEBP; Petroleum ether extract

Bidens pilosa L, belonging to the family of Acanthaceae, has been used as an anticancer medicine in folk in China. In our preliminary experiments, the petroleum ether extract from B. pilosa showed good cytotoxic activity to human lung cancer A549 cell. However, to date, it's lack of the further...