A physiological concentration of luteolin induces phase II drug-metabolizing enzymes through the ERK1/2 signaling pathway in HepG2 cells

• Published in: Archives of biochemistry and biophysics Vol. 663; pp. 151 - 159
• Main Authors: Kitakaze, Tomoya, Makiyama, Atsushi, Samukawa, Yumi, Jiang, Songyan, Yamashita, Yoko, Ashida, Hitoshi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.03.2019
• Subjects: Aldehyde dehydrogenase 2; Aldehyde Dehydrogenase, Mitochondrial - metabolism; Aldo-Keto Reductases - metabolism; Diet; Drug-metabolizing enzymes; Enzyme Activation; Enzymes - metabolism; Extracellular signal-regulated kinase 1/2; Glutathione Transferase - metabolism; Heme Oxygenase-1 - metabolism; Hep G2 Cells; Humans; Luteolin; Luteolin - administration & dosage; Luteolin - metabolism; MAP Kinase Signaling System; NAD(P)H Dehydrogenase (Quinone) - metabolism; NF-E2-Related Factor 2 - chemistry; NF-E2-Related Factor 2 - metabolism; Nuclear factor-erythroid-2-related factor 2; Phosphorylation; Ubiquitination; Aldehyde dehydrogenase 2; Luteolin; Drug-metabolizing enzymes; Extracellular signal-regulated kinase 1/2; Nuclear factor-erythroid-2-related factor 2

The flavon luteolin has various health-promoting activities including cardiovascular protection, anti-inflammatory activity and anticancer activity. A serum concentration of about 100 nM luteolin is reached by dietary habit. However, little is known about the function of luteolin over its physiologi...