A physiological concentration of luteolin induces phase II drug-metabolizing enzymes through the ERK1/2 signaling pathway in HepG2 cells
The flavon luteolin has various health-promoting activities including cardiovascular protection, anti-inflammatory activity and anticancer activity. A serum concentration of about 100 nM luteolin is reached by dietary habit. However, little is known about the function of luteolin over its physiologi...
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Published in | Archives of biochemistry and biophysics Vol. 663; pp. 151 - 159 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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15.03.2019
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Abstract | The flavon luteolin has various health-promoting activities including cardiovascular protection, anti-inflammatory activity and anticancer activity. A serum concentration of about 100 nM luteolin is reached by dietary habit. However, little is known about the function of luteolin over its physiological concentration range. In this study, we investigated whether a physiological concentration of luteolin could activate nuclear factor-erythroid-2-related factor 2 (Nrf2)-mediated expression of phase II drug-metabolizing enzymes in human hepatoma HepG2 cells. Interestingly, less than 1 nM of luteolin could induce phase II drug-metabolizing enzymes, such as GSTs, HO-1, and NQO1. Both 1 and 100 nM luteolin increased expression and activity of ALDH2, which metabolized toxic acetaldehyde into nontoxic acetic acid. Luteolin increased nuclear accumulation of Nrf2 and enhanced the ARE-binding complex through increasing the stability of the Nrf2 protein. Luteolin increased phosphorylation of Nrf2 at Ser40, and MEK inhibitors (U0126 and PD98059) canceled luteolin-induced phosphorylation of Nrf2. Furthermore, luteolin increased modified Keap1. In conclusion, a physiological concentration of luteolin induces the expression of phase II drug-metabolizing enzymes by enhancement of Nrf2 nuclear accumulation through MEK1/2-ERK1/2-mediated phosphorylation of Nrf2, increasing Nrf2 stability and inducing a conformational change of Keap1.
•Physiological concentration of luteolin modulated the Nrf2 pathway.•Luteolin induced phosphorylation of Nrf2 at Ser40 via the ERK1/2 signaling pathway.•Luteolin increased expression and activity of ALDH2. |
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AbstractList | The flavon luteolin has various health-promoting activities including cardiovascular protection, anti-inflammatory activity and anticancer activity. A serum concentration of about 100 nM luteolin is reached by dietary habit. However, little is known about the function of luteolin over its physiological concentration range. In this study, we investigated whether a physiological concentration of luteolin could activate nuclear factor-erythroid-2-related factor 2 (Nrf2)-mediated expression of phase II drug-metabolizing enzymes in human hepatoma HepG2 cells. Interestingly, less than 1 nM of luteolin could induce phase II drug-metabolizing enzymes, such as GSTs, HO-1, and NQO1. Both 1 and 100 nM luteolin increased expression and activity of ALDH2, which metabolized toxic acetaldehyde into nontoxic acetic acid. Luteolin increased nuclear accumulation of Nrf2 and enhanced the ARE-binding complex through increasing the stability of the Nrf2 protein. Luteolin increased phosphorylation of Nrf2 at Ser40, and MEK inhibitors (U0126 and PD98059) canceled luteolin-induced phosphorylation of Nrf2. Furthermore, luteolin increased modified Keap1. In conclusion, a physiological concentration of luteolin induces the expression of phase II drug-metabolizing enzymes by enhancement of Nrf2 nuclear accumulation through MEK1/2-ERK1/2-mediated phosphorylation of Nrf2, increasing Nrf2 stability and inducing a conformational change of Keap1.
•Physiological concentration of luteolin modulated the Nrf2 pathway.•Luteolin induced phosphorylation of Nrf2 at Ser40 via the ERK1/2 signaling pathway.•Luteolin increased expression and activity of ALDH2. The flavon luteolin has various health-promoting activities including cardiovascular protection, anti-inflammatory activity and anticancer activity. A serum concentration of about 100 nM luteolin is reached by dietary habit. However, little is known about the function of luteolin over its physiological concentration range. In this study, we investigated whether a physiological concentration of luteolin could activate nuclear factor-erythroid-2-related factor 2 (Nrf2)-mediated expression of phase II drug-metabolizing enzymes in human hepatoma HepG2 cells. Interestingly, less than 1 nM of luteolin could induce phase II drug-metabolizing enzymes, such as GSTs, HO-1, and NQO1. Both 1 and 100 nM luteolin increased expression and activity of ALDH2, which metabolized toxic acetaldehyde into nontoxic acetic acid. Luteolin increased nuclear accumulation of Nrf2 and enhanced the ARE-binding complex through increasing the stability of the Nrf2 protein. Luteolin increased phosphorylation of Nrf2 at Ser40, and MEK inhibitors (U0126 and PD98059) canceled luteolin-induced phosphorylation of Nrf2. Furthermore, luteolin increased modified Keap1. In conclusion, a physiological concentration of luteolin induces the expression of phase II drug-metabolizing enzymes by enhancement of Nrf2 nuclear accumulation through MEK1/2-ERK1/2-mediated phosphorylation of Nrf2, increasing Nrf2 stability and inducing a conformational change of Keap1. |
Author | Ashida, Hitoshi Makiyama, Atsushi Samukawa, Yumi Jiang, Songyan Kitakaze, Tomoya Yamashita, Yoko |
Author_xml | – sequence: 1 givenname: Tomoya surname: Kitakaze fullname: Kitakaze, Tomoya organization: Graduate School of Science, Technology and Innovation, Kobe University, Kobe, Hyogo, Japan – sequence: 2 givenname: Atsushi surname: Makiyama fullname: Makiyama, Atsushi organization: Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan – sequence: 3 givenname: Yumi surname: Samukawa fullname: Samukawa, Yumi organization: Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan – sequence: 4 givenname: Songyan surname: Jiang fullname: Jiang, Songyan organization: Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan – sequence: 5 givenname: Yoko surname: Yamashita fullname: Yamashita, Yoko organization: Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan – sequence: 6 givenname: Hitoshi surname: Ashida fullname: Ashida, Hitoshi email: ashida@kobe-u.ac.jp organization: Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30641047$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1371/journal.pone.0006588 10.1016/j.freeradbiomed.2014.01.025 10.1038/sj.emboj.7601950 10.1016/j.bbrc.2005.10.185 10.1016/j.jasms.2007.09.015 10.1016/j.fct.2017.08.016 10.1073/pnas.051618798 10.1242/bio.20134853 10.1002/mc.20234 10.1017/S000711450999170X 10.1016/j.freeradbiomed.2017.02.048 10.1074/jbc.M503346200 10.1073/pnas.081082098 10.1002/bdd.1956 10.1016/j.freeradbiomed.2011.03.008 10.1021/jf3008822 10.1074/jbc.M309660200 10.1074/jbc.M513737200 10.1016/j.freeradbiomed.2007.02.017 10.1152/physrev.00017.2013 10.1001/jama.296.10.1255 10.1128/MCB.00677-14 10.1016/j.siny.2004.11.001 10.1093/aje/155.8.732 10.1016/j.neuroscience.2015.07.057 10.1016/S0014-5793(98)01304-0 10.1074/jbc.M101053200 10.1271/bbb.66.1610 10.1158/1535-7163.MCT-06-0638 10.1002/biof.5520160303 10.1016/j.bbrc.2014.04.039 10.1016/j.intimp.2011.03.012 10.1002/oby.20559 10.1038/srep41017 10.1016/j.abb.2007.11.021 10.2337/db14-0631 10.1021/jf302831d 10.1101/gad.13.1.76 10.1021/tx100389r 10.1016/j.taap.2010.03.016 10.1038/srep25525 10.1053/j.gastro.2008.01.011 10.1128/MCB.23.22.8137-8151.2003 10.3164/jcbn.16-48 10.1093/alcalc/agt063 10.1128/MCB.01204-10 10.1038/srep37157 10.1016/j.cbi.2011.01.026 10.1021/tx0502138 10.1074/jbc.M206911200 |
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Keywords | Aldehyde dehydrogenase 2 Luteolin Drug-metabolizing enzymes Extracellular signal-regulated kinase 1/2 Nuclear factor-erythroid-2-related factor 2 |
Language | English |
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References | Chian, Thapa, Chi, Wang, Tang (bib47) 2014; 447 Yang, Tan, Lv, Liu, Baiyun, Lu, Zhang (bib25) 2016; 6 Holmström, Baird, Zhang, Hargreaves, Chalasani, Land, Stanyer, Yamamoto, Dinkova-Kostova, Abramov (bib14) 2013; 2 Nishiumi, Yamamoto, Kodoi, Fukuda, Yoshida, Ashida (bib26) 2008; 470 C. Hu, A.L. Eggler, A.D. Mesecar, R.B. van Breemen, Modification of keap1 cysteine residues by sulforaphane, Chem. Res. Toxicol.. 24 (4) 515-521. Itoh, Wakabayashi, Katoh, Ishii, Igarashi, Engel, Yamamoto (bib32) 1999; 13 Cao, Zhang, Chen, Zhao (bib6) 2010; 103 Lamlé, Marhenke, Borlak, von Wasielewski, Eriksson, Geffers, Manns, Yamamoto, Vogel (bib16) 2008; 134 Ushida, Talalay (bib18) 2013; 48 Mitani, Yoshioka, Furuyashiki, Yamashita, Shirai, Ashida (bib39) 2017; 106 Tang, Wang, Fan, Wu, Ren, Wang (bib46) 2011; 50 Gaikwad, 2nd Long, Stringer, Jaiswal (bib52) 2001; 276 Blake, Castro, Leeder, Kearns (bib50) 2005; 10 Kuriyama, Shimazu, Ohmori, Kikuchi, Nakaya, Nishino, Tsubono, Tsuji (bib1) 2006; 296 Hong, Sekhar, Freeman, Liebler (bib28) 2005; 280 Kwon, Jung, Park, Yun, Choi (bib3) 2015; 64 Nishinaka, Miura, Okumura, Nakao, Nakamura, Terada (bib11) 2011; 191 Shimoi, Okada, Furugori, Goda, Takase, Suzuki, Hara, Yamamoto, Kinae (bib7) 1988; 438 Shi, Huang, Zhu, Ong, Zhao, Lu, Ong, Shen (bib24) 2007; 6 Chan, Han, Kan (bib13) 2001; 98 Liu, Yamanaka, Abe-Kanoh, Liu, Zhu, Munemasa, Nakamura, Murata, Nakamura (bib48) 2017; 108 Martin, Rojo, Salinas, Diaz, Gallardo, Alam, De Galarreta, Cuadrado (bib9) 2004; 279 Rada, Rojo, Chowdhry, McMahon, Hayes, Cuadrado (bib44) 2011; 31 Wu, Yano, Hisanaga, He, Sakao, Hou (bib5) 2017; 61 Ramos-Gome, Kwak, Dolan, Itoh, Yamamoto, Talalay, Kensler (bib8) 2001; 98 Meakin, Chowdhry, Sharma, Ashford, Walsh, McCrimmon, Dinkova-Kostova, Dillon, Hayes, Ashford (bib15) 2014; 34 Zhang, Yeager, Tanaka, Klaassen (bib17) 2010; 245 Chen, Ferreira, Gross, Mochly-Rosen (bib49) 2014; 94 Okawa, Motohashi, Kobayashi, Aburatani, Kensler, Yamamoto (bib19) 2006; 339 Hu, Xu, Wu, Pan, Chen, Chen, Zhang, Zhu, Li (bib22) 2017; 7 Sun, Huang, Zhang (bib37) 2009; 4 Tanigawa, Fujii, Hou (bib20) 2007; 42 Zhang, Hannink (bib29) 2003; 23 Huang, Nguyen, Pickett (bib36) 2002; 277 Zhang, Liu, Jiang, Li, Zhao, Cao, Yao (bib41) 2014; 69 Paredes-Gonzalez, Fuentes, Jeffery, Saw, Shu, Su, Kong (bib40) 2015; 36 Hong, Freeman, Liebler (bib30) 2005; 18 Checkoway, Powers, Smith-Weller, Franklin, Longstreth, Swanson (bib2) 2002; 155 Y. Luo, A.L. Eggler, D. Liu D, G. Liu, A.D. Mesecar, R.B. van Breemen, Sites of alkylation of human Keap1 by natural chemoprevention agents, J. Am. Soc. Mass Spectrom.. 18 (12) 2226-2232. Murakami, Koshimizu, Ohigashi, Kuwahara, Kuki, Takahashi, Hosotani, Kawahara, Matsuoka (bib31) 2002; 16 Cheng, Cheng, Chiou, Chang (bib21) 2012; 60 Zhu, Wang, Wang, Du, Hu, Li, Feng, Zhu, Mo, Cao, Li, Yu (bib45) 2015; 304 Li, Yang, Gong, Yang, Li, Zhao, Yao, Jiang, Cao (bib42) 2016; 6 Yoshioka, Li, Mitani, Yasuda, Nanba, Toda, Ashida (bib4) 2017; 60 Beyer, Xu, Teupser, auf dem Keller, Bugnon, Hildt, Thiery, Kan, Werner (bib12) 2008; 27 Hashimoto, Nonaka, Minato, Kawakami, Mizuno, Fukuda, Kanazawa, Ashida (bib27) 2002; 66 Funakoshi-Tago, Nakamura, Tago, Mashino, Kasahara (bib23) 2011; 11 Alam, Stewart, Touchard, Boinapally, Choi, Cook (bib10) 1999; 274 Yuan, Xu, Pan, Keum, Kim, Shen, Yu, Oo, Ma, Kong (bib38) 2006; 45 Jr Hinds, Sodhi, Meadows, Fedorova, Puri, Kim, Peterson, Shapiro, Abraham, Kappas (bib51) 2014; 22 Salazar, Rojo, Velasco, de Sagarra, Cuadrado (bib43) 2006; 281 Fujimoto, Masuda (bib35) 2012; 60 Huang (10.1016/j.abb.2019.01.012_bib36) 2002; 277 Shi (10.1016/j.abb.2019.01.012_bib24) 2007; 6 Paredes-Gonzalez (10.1016/j.abb.2019.01.012_bib40) 2015; 36 Chian (10.1016/j.abb.2019.01.012_bib47) 2014; 447 Nishinaka (10.1016/j.abb.2019.01.012_bib11) 2011; 191 Itoh (10.1016/j.abb.2019.01.012_bib32) 1999; 13 Salazar (10.1016/j.abb.2019.01.012_bib43) 2006; 281 Chen (10.1016/j.abb.2019.01.012_bib49) 2014; 94 Yoshioka (10.1016/j.abb.2019.01.012_bib4) 2017; 60 Martin (10.1016/j.abb.2019.01.012_bib9) 2004; 279 Wu (10.1016/j.abb.2019.01.012_bib5) 2017; 61 Meakin (10.1016/j.abb.2019.01.012_bib15) 2014; 34 Funakoshi-Tago (10.1016/j.abb.2019.01.012_bib23) 2011; 11 Tang (10.1016/j.abb.2019.01.012_bib46) 2011; 50 Lamlé (10.1016/j.abb.2019.01.012_bib16) 2008; 134 Zhang (10.1016/j.abb.2019.01.012_bib29) 2003; 23 Holmström (10.1016/j.abb.2019.01.012_bib14) 2013; 2 Fujimoto (10.1016/j.abb.2019.01.012_bib35) 2012; 60 Gaikwad (10.1016/j.abb.2019.01.012_bib52) 2001; 276 Ushida (10.1016/j.abb.2019.01.012_bib18) 2013; 48 Liu (10.1016/j.abb.2019.01.012_bib48) 2017; 108 Cao (10.1016/j.abb.2019.01.012_bib6) 2010; 103 Chan (10.1016/j.abb.2019.01.012_bib13) 2001; 98 Okawa (10.1016/j.abb.2019.01.012_bib19) 2006; 339 Kwon (10.1016/j.abb.2019.01.012_bib3) 2015; 64 Nishiumi (10.1016/j.abb.2019.01.012_bib26) 2008; 470 Cheng (10.1016/j.abb.2019.01.012_bib21) 2012; 60 Zhang (10.1016/j.abb.2019.01.012_bib41) 2014; 69 Hashimoto (10.1016/j.abb.2019.01.012_bib27) 2002; 66 Tanigawa (10.1016/j.abb.2019.01.012_bib20) 2007; 42 Mitani (10.1016/j.abb.2019.01.012_bib39) 2017; 106 Hu (10.1016/j.abb.2019.01.012_bib22) 2017; 7 Alam (10.1016/j.abb.2019.01.012_bib10) 1999; 274 10.1016/j.abb.2019.01.012_bib34 10.1016/j.abb.2019.01.012_bib33 Hong (10.1016/j.abb.2019.01.012_bib30) 2005; 18 Zhang (10.1016/j.abb.2019.01.012_bib17) 2010; 245 Blake (10.1016/j.abb.2019.01.012_bib50) 2005; 10 Rada (10.1016/j.abb.2019.01.012_bib44) 2011; 31 Yuan (10.1016/j.abb.2019.01.012_bib38) 2006; 45 Li (10.1016/j.abb.2019.01.012_bib42) 2016; 6 Checkoway (10.1016/j.abb.2019.01.012_bib2) 2002; 155 Sun (10.1016/j.abb.2019.01.012_bib37) 2009; 4 Jr Hinds (10.1016/j.abb.2019.01.012_bib51) 2014; 22 Shimoi (10.1016/j.abb.2019.01.012_bib7) 1988; 438 Murakami (10.1016/j.abb.2019.01.012_bib31) 2002; 16 Zhu (10.1016/j.abb.2019.01.012_bib45) 2015; 304 Kuriyama (10.1016/j.abb.2019.01.012_bib1) 2006; 296 Beyer (10.1016/j.abb.2019.01.012_bib12) 2008; 27 Yang (10.1016/j.abb.2019.01.012_bib25) 2016; 6 Hong (10.1016/j.abb.2019.01.012_bib28) 2005; 280 Ramos-Gome (10.1016/j.abb.2019.01.012_bib8) 2001; 98 |
References_xml | – volume: 98 start-page: 4611 year: 2001 end-page: 4616 ident: bib13 article-title: An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Kan – volume: 103 start-page: 249 year: 2010 end-page: 255 ident: bib6 article-title: The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake publication-title: Br. J. Nutr. contributor: fullname: Zhao – volume: 98 start-page: 3410 year: 2001 end-page: 3415 ident: bib8 article-title: Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Kensler – volume: 274 start-page: 26071 year: 1999 end-page: 27078 ident: bib10 article-title: Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene contributor: fullname: Cook – volume: 60 start-page: 5142 year: 2012 end-page: 5151 ident: bib35 article-title: Chemical interaction between polyphenols and a cysteinyl thiol under radical oxidation conditions publication-title: J. Agric. Food Chem. contributor: fullname: Masuda – volume: 191 start-page: 185 year: 2011 end-page: 191 ident: bib11 article-title: Regulation of aldo-keto reductase AKR1B10 gene expression: involvement of transcription factor Nrf2 publication-title: Chem. Biol. Interact. contributor: fullname: Terada – volume: 34 start-page: 3305 year: 2014 end-page: 3320 ident: bib15 article-title: Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance publication-title: Mol. Cell Biol. contributor: fullname: Ashford – volume: 438 start-page: 220 year: 1988 end-page: 224 ident: bib7 article-title: Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans publication-title: FEBS Lett. contributor: fullname: Kinae – volume: 155 start-page: 732 year: 2002 end-page: 738 ident: bib2 article-title: Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake publication-title: Am. J. Epidemiol. contributor: fullname: Swanson – volume: 64 start-page: 1658 year: 2015 end-page: 1669 ident: bib3 article-title: Luteolin attenuates hepatic steatosis and insulin resistance through the interplay between the liver and adipose tissue in mice with diet-induced obesity publication-title: Diabetes contributor: fullname: Choi – volume: 280 start-page: 31768 year: 2005 end-page: 31775 ident: bib28 article-title: Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation publication-title: J. Biol. Chem. contributor: fullname: Liebler – volume: 10 start-page: 123 year: 2005 end-page: 138 ident: bib50 article-title: Ontogeny of drug metabolizing enzymes in the neonate publication-title: Semin. Fetal Neonatal Med. contributor: fullname: Kearns – volume: 48 start-page: 526 year: 2013 end-page: 534 ident: bib18 article-title: Sulforaphane accelerates acetaldehyde metabolism by inducing aldehyde dehydrogenases: relevance to ethanol intolerance publication-title: Alcohol Alcohol contributor: fullname: Talalay – volume: 69 start-page: 219 year: 2014 end-page: 228 ident: bib41 article-title: Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling publication-title: Free Radic. Biol. Med. contributor: fullname: Yao – volume: 108 start-page: 305 year: 2017 end-page: 313 ident: bib48 article-title: Benzyl isothiocyanate ameliorates acetaldehyde-induced cytotoxicity by enhancing aldehyde dehydrogenase activity in murine hepatoma Hepa1c1c7 cells publication-title: Food Chem. Toxicol. contributor: fullname: Nakamura – volume: 7 start-page: 41017 year: 2017 ident: bib22 article-title: Luteolin improves cardiac dysfunction in heart failure rats by regulating sarcoplasmic reticulum Ca2 publication-title: Sci. Rep. contributor: fullname: Li – volume: 61 year: 2017 ident: bib5 article-title: Polyphenols from Lonicera caerulea L. berry attenuate experimental nonalcoholic steatohepatitis by inhibiting proinflammatory cytokines productions and lipid peroxidation publication-title: Mol. Nutr. Food Res. contributor: fullname: Hou – volume: 276 start-page: 22559 year: 2001 end-page: 22564 ident: bib52 article-title: In vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the regulation of intracellular redox state and accumulation of abdominal adipose tissue publication-title: J. Biol. Chem. contributor: fullname: Jaiswal – volume: 6 start-page: 37157 year: 2016 ident: bib25 article-title: Regulation of Sirt1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity publication-title: Sci. Rep. contributor: fullname: Zhang – volume: 27 start-page: 212 year: 2008 end-page: 223 ident: bib12 article-title: Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance publication-title: EMBO J. contributor: fullname: Werner – volume: 18 start-page: 1917 year: 2005 end-page: 1926 ident: bib30 article-title: Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane publication-title: Chem. Res. Toxicol. contributor: fullname: Liebler – volume: 94 start-page: 1 year: 2014 end-page: 34 ident: bib49 article-title: Targeting aldehyde dehydrogenase 2: new therapeutic opportunities publication-title: Physiol. Rev. contributor: fullname: Mochly-Rosen – volume: 304 start-page: 328 year: 2015 end-page: 339 ident: bib45 article-title: 17β-Estradiol up-regulates Nrf2 via PI3K/AKT and estrogen receptor signaling pathways to suppress light-induced degeneration in rat retina publication-title: Neuroscience contributor: fullname: Yu – volume: 22 start-page: 705 year: 2014 end-page: 712 ident: bib51 article-title: Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21 publication-title: Obesity contributor: fullname: Kappas – volume: 13 start-page: 76 year: 1999 end-page: 86 ident: bib32 article-title: Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain publication-title: Genes Dev. contributor: fullname: Yamamoto – volume: 296 start-page: 1255 year: 2006 end-page: 1265 ident: bib1 article-title: Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study publication-title: J. Am. Med. Assoc. contributor: fullname: Tsuji – volume: 60 start-page: 9180 year: 2012 end-page: 9187 ident: bib21 article-title: Resveratrol upregulates Nrf2 expression to attenuate methylglyoxal-induced insulin resistance in Hep G2 cells publication-title: J. Agric. Food Chem. contributor: fullname: Chang – volume: 11 start-page: 1150 year: 2011 end-page: 1159 ident: bib23 article-title: Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin publication-title: Int. Immunopharm. contributor: fullname: Kasahara – volume: 277 start-page: 42769 year: 2002 end-page: 42774 ident: bib36 article-title: Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription publication-title: J. Biol. Chem. contributor: fullname: Pickett – volume: 16 start-page: 73 year: 2002 end-page: 82 ident: bib31 article-title: Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin publication-title: Biofactors contributor: fullname: Matsuoka – volume: 245 start-page: 326 year: 2010 end-page: 334 ident: bib17 article-title: Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet publication-title: Toxicol. Appl. Pharmacol. contributor: fullname: Klaassen – volume: 106 start-page: 355 year: 2017 end-page: 367 ident: bib39 article-title: Enzymatically synthesized glycogen inhibits colitis through decreasing oxidative stress publication-title: Free Radic. Biol. Med. contributor: fullname: Ashida – volume: 281 start-page: 14841 year: 2006 end-page: 14851 ident: bib43 article-title: Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2 publication-title: J. Biol. Chem. contributor: fullname: Cuadrado – volume: 42 start-page: 1690 year: 2007 end-page: 1703 ident: bib20 article-title: Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin publication-title: Free Radic. Biol. Med. contributor: fullname: Hou – volume: 45 start-page: 841 year: 2006 end-page: 850 ident: bib38 article-title: Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells publication-title: Mol. Carcinog. contributor: fullname: Kong – volume: 339 start-page: 79 year: 2006 end-page: 88 ident: bib19 article-title: Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Yamamoto – volume: 4 start-page: e6588 year: 2009 ident: bib37 article-title: Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response publication-title: PLoS One contributor: fullname: Zhang – volume: 470 start-page: 187 year: 2008 end-page: 199 ident: bib26 article-title: Antagonistic and agonistic effects of indigoids on the transformation of an aryl hydrocarbon receptor publication-title: Arch. Biochem. Biophys. contributor: fullname: Ashida – volume: 6 start-page: 25525 year: 2016 ident: bib42 article-title: 3H-1,2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling publication-title: Sci. Rep. contributor: fullname: Cao – volume: 23 start-page: 8137 year: 2003 end-page: 8151 ident: bib29 article-title: Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress publication-title: Mol. Cell Biol. contributor: fullname: Hannink – volume: 66 start-page: 1610 year: 2002 end-page: 1614 ident: bib27 article-title: Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice publication-title: Biosci. Biotechnol. Biochem. contributor: fullname: Ashida – volume: 134 start-page: 1159 year: 2008 end-page: 1168 ident: bib16 publication-title: Gastroenterology contributor: fullname: Vogel – volume: 2 start-page: 761 year: 2013 end-page: 770 ident: bib14 article-title: Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration publication-title: Biol. Open contributor: fullname: Abramov – volume: 447 start-page: 602 year: 2014 end-page: 608 ident: bib47 article-title: Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Tang – volume: 50 start-page: 1599 year: 2011 end-page: 1609 ident: bib46 article-title: Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs publication-title: Free Radic. Biol. Med. contributor: fullname: Wang – volume: 36 start-page: 440 year: 2015 end-page: 451 ident: bib40 article-title: Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin publication-title: Biopharm Drug Dispos. contributor: fullname: Kong – volume: 31 start-page: 1121 year: 2011 end-page: 1133 ident: bib44 article-title: SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner publication-title: Mol. Cell Biol. contributor: fullname: Cuadrado – volume: 6 start-page: 1338 year: 2007 end-page: 1347 ident: bib24 article-title: Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization publication-title: Mol. Canc. Therapeut. contributor: fullname: Shen – volume: 60 start-page: 108 year: 2017 end-page: 114 ident: bib4 article-title: Black soybean seed coat polyphenols prevent AAPH-induced oxidative DNA-damage in HepG2 cells publication-title: J. Clin. Biochem. Nutr. contributor: fullname: Ashida – volume: 279 start-page: 8919 year: 2004 end-page: 8929 ident: bib9 article-title: Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol publication-title: J. Biol. Chem. contributor: fullname: Cuadrado – volume: 4 start-page: e6588 issue: 8 year: 2009 ident: 10.1016/j.abb.2019.01.012_bib37 article-title: Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response publication-title: PLoS One doi: 10.1371/journal.pone.0006588 contributor: fullname: Sun – volume: 69 start-page: 219 year: 2014 ident: 10.1016/j.abb.2019.01.012_bib41 article-title: Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2014.01.025 contributor: fullname: Zhang – volume: 27 start-page: 212 issue: 1 year: 2008 ident: 10.1016/j.abb.2019.01.012_bib12 article-title: Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance publication-title: EMBO J. doi: 10.1038/sj.emboj.7601950 contributor: fullname: Beyer – volume: 339 start-page: 79 issue: 1 year: 2006 ident: 10.1016/j.abb.2019.01.012_bib19 article-title: Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2005.10.185 contributor: fullname: Okawa – ident: 10.1016/j.abb.2019.01.012_bib34 doi: 10.1016/j.jasms.2007.09.015 – volume: 108 start-page: 305 year: 2017 ident: 10.1016/j.abb.2019.01.012_bib48 article-title: Benzyl isothiocyanate ameliorates acetaldehyde-induced cytotoxicity by enhancing aldehyde dehydrogenase activity in murine hepatoma Hepa1c1c7 cells publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2017.08.016 contributor: fullname: Liu – volume: 98 start-page: 3410 issue: 6 year: 2001 ident: 10.1016/j.abb.2019.01.012_bib8 article-title: Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.051618798 contributor: fullname: Ramos-Gome – volume: 2 start-page: 761 issue: 8 year: 2013 ident: 10.1016/j.abb.2019.01.012_bib14 article-title: Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration publication-title: Biol. Open doi: 10.1242/bio.20134853 contributor: fullname: Holmström – volume: 45 start-page: 841 issue: 11 year: 2006 ident: 10.1016/j.abb.2019.01.012_bib38 article-title: Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells publication-title: Mol. Carcinog. doi: 10.1002/mc.20234 contributor: fullname: Yuan – volume: 103 start-page: 249 issue: 2 year: 2010 ident: 10.1016/j.abb.2019.01.012_bib6 article-title: The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake publication-title: Br. J. Nutr. doi: 10.1017/S000711450999170X contributor: fullname: Cao – volume: 106 start-page: 355 year: 2017 ident: 10.1016/j.abb.2019.01.012_bib39 article-title: Enzymatically synthesized glycogen inhibits colitis through decreasing oxidative stress publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2017.02.048 contributor: fullname: Mitani – volume: 280 start-page: 31768 issue: 36 year: 2005 ident: 10.1016/j.abb.2019.01.012_bib28 article-title: Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M503346200 contributor: fullname: Hong – volume: 98 start-page: 4611 issue: 8 year: 2001 ident: 10.1016/j.abb.2019.01.012_bib13 article-title: An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.081082098 contributor: fullname: Chan – volume: 36 start-page: 440 issue: 7 year: 2015 ident: 10.1016/j.abb.2019.01.012_bib40 article-title: Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin publication-title: Biopharm Drug Dispos. doi: 10.1002/bdd.1956 contributor: fullname: Paredes-Gonzalez – volume: 50 start-page: 1599 issue: 11 year: 2011 ident: 10.1016/j.abb.2019.01.012_bib46 article-title: Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2011.03.008 contributor: fullname: Tang – volume: 60 start-page: 5142 issue: 20 year: 2012 ident: 10.1016/j.abb.2019.01.012_bib35 article-title: Chemical interaction between polyphenols and a cysteinyl thiol under radical oxidation conditions publication-title: J. Agric. Food Chem. doi: 10.1021/jf3008822 contributor: fullname: Fujimoto – volume: 279 start-page: 8919 issue: 10 year: 2004 ident: 10.1016/j.abb.2019.01.012_bib9 article-title: Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol publication-title: J. Biol. Chem. doi: 10.1074/jbc.M309660200 contributor: fullname: Martin – volume: 281 start-page: 14841 issue: 21 year: 2006 ident: 10.1016/j.abb.2019.01.012_bib43 article-title: Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M513737200 contributor: fullname: Salazar – volume: 42 start-page: 1690 issue: 11 year: 2007 ident: 10.1016/j.abb.2019.01.012_bib20 article-title: Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2007.02.017 contributor: fullname: Tanigawa – volume: 94 start-page: 1 issue: 1 year: 2014 ident: 10.1016/j.abb.2019.01.012_bib49 article-title: Targeting aldehyde dehydrogenase 2: new therapeutic opportunities publication-title: Physiol. Rev. doi: 10.1152/physrev.00017.2013 contributor: fullname: Chen – volume: 296 start-page: 1255 issue: 10 year: 2006 ident: 10.1016/j.abb.2019.01.012_bib1 article-title: Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study publication-title: J. Am. Med. Assoc. doi: 10.1001/jama.296.10.1255 contributor: fullname: Kuriyama – volume: 34 start-page: 3305 issue: 17 year: 2014 ident: 10.1016/j.abb.2019.01.012_bib15 publication-title: Mol. Cell Biol. doi: 10.1128/MCB.00677-14 contributor: fullname: Meakin – volume: 10 start-page: 123 issue: 2 year: 2005 ident: 10.1016/j.abb.2019.01.012_bib50 article-title: Ontogeny of drug metabolizing enzymes in the neonate publication-title: Semin. Fetal Neonatal Med. doi: 10.1016/j.siny.2004.11.001 contributor: fullname: Blake – volume: 155 start-page: 732 issue: 8 year: 2002 ident: 10.1016/j.abb.2019.01.012_bib2 article-title: Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake publication-title: Am. J. Epidemiol. doi: 10.1093/aje/155.8.732 contributor: fullname: Checkoway – volume: 304 start-page: 328 year: 2015 ident: 10.1016/j.abb.2019.01.012_bib45 article-title: 17β-Estradiol up-regulates Nrf2 via PI3K/AKT and estrogen receptor signaling pathways to suppress light-induced degeneration in rat retina publication-title: Neuroscience doi: 10.1016/j.neuroscience.2015.07.057 contributor: fullname: Zhu – volume: 438 start-page: 220 issue: 3 year: 1988 ident: 10.1016/j.abb.2019.01.012_bib7 article-title: Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans publication-title: FEBS Lett. doi: 10.1016/S0014-5793(98)01304-0 contributor: fullname: Shimoi – volume: 276 start-page: 22559 issue: 25 year: 2001 ident: 10.1016/j.abb.2019.01.012_bib52 article-title: In vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the regulation of intracellular redox state and accumulation of abdominal adipose tissue publication-title: J. Biol. Chem. doi: 10.1074/jbc.M101053200 contributor: fullname: Gaikwad – volume: 274 start-page: 26071 issue: 37 year: 1999 ident: 10.1016/j.abb.2019.01.012_bib10 article-title: Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene contributor: fullname: Alam – volume: 66 start-page: 1610 issue: 7 year: 2002 ident: 10.1016/j.abb.2019.01.012_bib27 article-title: Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice publication-title: Biosci. Biotechnol. Biochem. doi: 10.1271/bbb.66.1610 contributor: fullname: Hashimoto – volume: 6 start-page: 1338 issue: 4 year: 2007 ident: 10.1016/j.abb.2019.01.012_bib24 article-title: Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization publication-title: Mol. Canc. Therapeut. doi: 10.1158/1535-7163.MCT-06-0638 contributor: fullname: Shi – volume: 16 start-page: 73 issue: 3–4 year: 2002 ident: 10.1016/j.abb.2019.01.012_bib31 article-title: Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin publication-title: Biofactors doi: 10.1002/biof.5520160303 contributor: fullname: Murakami – volume: 447 start-page: 602 issue: 4 year: 2014 ident: 10.1016/j.abb.2019.01.012_bib47 article-title: Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2014.04.039 contributor: fullname: Chian – volume: 61 issue: 4 year: 2017 ident: 10.1016/j.abb.2019.01.012_bib5 article-title: Polyphenols from Lonicera caerulea L. berry attenuate experimental nonalcoholic steatohepatitis by inhibiting proinflammatory cytokines productions and lipid peroxidation publication-title: Mol. Nutr. Food Res. contributor: fullname: Wu – volume: 11 start-page: 1150 issue: 9 year: 2011 ident: 10.1016/j.abb.2019.01.012_bib23 article-title: Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin publication-title: Int. Immunopharm. doi: 10.1016/j.intimp.2011.03.012 contributor: fullname: Funakoshi-Tago – volume: 22 start-page: 705 issue: 3 year: 2014 ident: 10.1016/j.abb.2019.01.012_bib51 article-title: Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21 publication-title: Obesity doi: 10.1002/oby.20559 contributor: fullname: Jr Hinds – volume: 7 start-page: 41017 year: 2017 ident: 10.1016/j.abb.2019.01.012_bib22 article-title: Luteolin improves cardiac dysfunction in heart failure rats by regulating sarcoplasmic reticulum Ca2+-ATPase 2a publication-title: Sci. Rep. doi: 10.1038/srep41017 contributor: fullname: Hu – volume: 470 start-page: 187 issue: 2 year: 2008 ident: 10.1016/j.abb.2019.01.012_bib26 article-title: Antagonistic and agonistic effects of indigoids on the transformation of an aryl hydrocarbon receptor publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2007.11.021 contributor: fullname: Nishiumi – volume: 64 start-page: 1658 issue: 5 year: 2015 ident: 10.1016/j.abb.2019.01.012_bib3 article-title: Luteolin attenuates hepatic steatosis and insulin resistance through the interplay between the liver and adipose tissue in mice with diet-induced obesity publication-title: Diabetes doi: 10.2337/db14-0631 contributor: fullname: Kwon – volume: 60 start-page: 9180 issue: 36 year: 2012 ident: 10.1016/j.abb.2019.01.012_bib21 article-title: Resveratrol upregulates Nrf2 expression to attenuate methylglyoxal-induced insulin resistance in Hep G2 cells publication-title: J. Agric. Food Chem. doi: 10.1021/jf302831d contributor: fullname: Cheng – volume: 13 start-page: 76 issue: 1 year: 1999 ident: 10.1016/j.abb.2019.01.012_bib32 article-title: Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain publication-title: Genes Dev. doi: 10.1101/gad.13.1.76 contributor: fullname: Itoh – ident: 10.1016/j.abb.2019.01.012_bib33 doi: 10.1021/tx100389r – volume: 245 start-page: 326 issue: 3 year: 2010 ident: 10.1016/j.abb.2019.01.012_bib17 article-title: Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2010.03.016 contributor: fullname: Zhang – volume: 6 start-page: 25525 year: 2016 ident: 10.1016/j.abb.2019.01.012_bib42 article-title: 3H-1,2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling publication-title: Sci. Rep. doi: 10.1038/srep25525 contributor: fullname: Li – volume: 134 start-page: 1159 issue: 4 year: 2008 ident: 10.1016/j.abb.2019.01.012_bib16 publication-title: Gastroenterology doi: 10.1053/j.gastro.2008.01.011 contributor: fullname: Lamlé – volume: 23 start-page: 8137 issue: 22 year: 2003 ident: 10.1016/j.abb.2019.01.012_bib29 article-title: Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress publication-title: Mol. Cell Biol. doi: 10.1128/MCB.23.22.8137-8151.2003 contributor: fullname: Zhang – volume: 60 start-page: 108 issue: 2 year: 2017 ident: 10.1016/j.abb.2019.01.012_bib4 article-title: Black soybean seed coat polyphenols prevent AAPH-induced oxidative DNA-damage in HepG2 cells publication-title: J. Clin. Biochem. Nutr. doi: 10.3164/jcbn.16-48 contributor: fullname: Yoshioka – volume: 48 start-page: 526 issue: 5 year: 2013 ident: 10.1016/j.abb.2019.01.012_bib18 article-title: Sulforaphane accelerates acetaldehyde metabolism by inducing aldehyde dehydrogenases: relevance to ethanol intolerance publication-title: Alcohol Alcohol doi: 10.1093/alcalc/agt063 contributor: fullname: Ushida – volume: 31 start-page: 1121 issue: 6 year: 2011 ident: 10.1016/j.abb.2019.01.012_bib44 article-title: SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner publication-title: Mol. Cell Biol. doi: 10.1128/MCB.01204-10 contributor: fullname: Rada – volume: 6 start-page: 37157 year: 2016 ident: 10.1016/j.abb.2019.01.012_bib25 article-title: Regulation of Sirt1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity publication-title: Sci. Rep. doi: 10.1038/srep37157 contributor: fullname: Yang – volume: 191 start-page: 185 issue: 1–3 year: 2011 ident: 10.1016/j.abb.2019.01.012_bib11 article-title: Regulation of aldo-keto reductase AKR1B10 gene expression: involvement of transcription factor Nrf2 publication-title: Chem. Biol. Interact. doi: 10.1016/j.cbi.2011.01.026 contributor: fullname: Nishinaka – volume: 18 start-page: 1917 issue: 12 year: 2005 ident: 10.1016/j.abb.2019.01.012_bib30 article-title: Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane publication-title: Chem. Res. Toxicol. doi: 10.1021/tx0502138 contributor: fullname: Hong – volume: 277 start-page: 42769 issue: 45 year: 2002 ident: 10.1016/j.abb.2019.01.012_bib36 article-title: Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription publication-title: J. Biol. Chem. doi: 10.1074/jbc.M206911200 contributor: fullname: Huang |
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SubjectTerms | Aldehyde dehydrogenase 2 Aldehyde Dehydrogenase, Mitochondrial - metabolism Aldo-Keto Reductases - metabolism Diet Drug-metabolizing enzymes Enzyme Activation Enzymes - metabolism Extracellular signal-regulated kinase 1/2 Glutathione Transferase - metabolism Heme Oxygenase-1 - metabolism Hep G2 Cells Humans Luteolin Luteolin - administration & dosage Luteolin - metabolism MAP Kinase Signaling System NAD(P)H Dehydrogenase (Quinone) - metabolism NF-E2-Related Factor 2 - chemistry NF-E2-Related Factor 2 - metabolism Nuclear factor-erythroid-2-related factor 2 Phosphorylation Ubiquitination |
Title | A physiological concentration of luteolin induces phase II drug-metabolizing enzymes through the ERK1/2 signaling pathway in HepG2 cells |
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