Crosstalk between immune checkpoint and DNA damage response inhibitors for radiosensitization of tumors

• Published in: Strahlentherapie und Onkologie Vol. 199; no. 12; pp. 1152 - 1163
• Main Authors: Classen, Sandra, Petersen, Cordula, Borgmann, Kerstin
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2023; Springer Nature B.V
• Subjects: Cell death; DNA damage; DNA repair; Immune system; Inhibitors; Medicine; Medicine & Public Health; Oncology; Radiation; Radiation damage; Radiation therapy; Radiation tolerance; Radiotherapy; Review Article; Tumors; cGAS/STING activation; DNA damage response; DNA repair; Cytosolic dsDNA; PARP inhibition

Purpose This review article is intended to provide a perspective overview of potential strategies to overcome radiation resistance of tumors through the combined use of immune checkpoint and DNA repair inhibitors. Methods A literature search was conducted in PubMed using the terms (“DNA repair* and...