Dual medication therapy (acetaminophen and ibuprofen) for the management of patent ductus arteriosus in preterm infants: a systematic review and meta-analysis

• Published in: Journal of perinatology Vol. 42; no. 12; pp. 1654 - 1661
• Main Authors: Shah, Sanket D., Makker, Kartikeya, Zhang, Mingyu, Harnett, Susan, Aziz, Khyzer B., Hudak, Mark L.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2022; Nature Publishing Group
• Subjects: 631/443/592/75/1539; 692/699/75/1539; Acetaminophen; Analgesics; Clinical trials; Congenital diseases; Coronary vessels; Drug therapy; Ductus Arteriosus, Patent - drug therapy; Dysplasia; Enterocolitis; FDA approval; Gestational age; Humans; Ibuprofen; Ibuprofen - adverse effects; Ibuprofen - therapeutic use; Indomethacin; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Infants; Librarians; Lung diseases; Medicine; Medicine & Public Health; Meta-analysis; Necrotizing enterocolitis; Neonates; Newborn babies; Nonsteroidal anti-inflammatory drugs; Pediatric Surgery; Pediatrics; Population studies; Premature babies; Renal function; Sepsis; Systematic review; Therapy

Objective To examine the efficacy of dual medication therapy (intervention) (DMT: acetaminophen and ibuprofen) vs. single medication therapy (control) (SMT: ibuprofen) for medical management of PDA (outcomes) in preterm infants (population). Study design We systematically searched multiple sources t...