Renal lipid accumulation induced by high-fat diet regulates glucose homeostasis via sodium-glucose cotransporter 2

• Published in: Diabetes research and clinical practice Vol. 179; p. 109027
• Main Authors: Chen, Juan, Li, Tingting, Vladmir, Carvalho, Yuan, Yang, Sun, Zilin
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.09.2021
• Subjects: Animals; Diet, High-Fat - adverse effects; Glucose; Glucose reabsorption; Homeostasis; Humans; Kidney; Lipid accumulation; Lipids; Rats; Sodium; Sodium-glucose cotransporter 2; Sodium-Glucose Transporter 2 - genetics; Lipid accumulation; Glucose reabsorption; Sodium-glucose cotransporter 2

Visceral lipid accumulation is involved in a variety of physiological aberrations. In the current study, we aimed to investigate whether lipid accumulation had an impact on glucose reabsorption in the kidney. We examined renal lipid content and renal threshold for glucose (RTG) of each subject. We c...