Dual aggregation-induced emission for enhanced fluorescence sensing of furin activity in vitro and in living cells

• Published in: Chemical communications (Cambridge, England) Vol. 53; no. 6; pp. 1037 - 1040
• Main Authors: Liu, Xiaomei, Liang, Gaolin
• Format: Journal Article
• Language: English
• Published: England 2017
• Subjects: Biomarkers; Cell Survival; Cells (biology); chemical compounds; Condensation; condensation reactions; Detection; Emission; emissions; enzyme activity; Fluorescence; Fluorescent Dyes - chemistry; Furin - analysis; Furin - metabolism; Humans; image analysis; In Vitro Techniques; In vitro testing; Molecular Structure; Optical Imaging; Strategy; Tumor Cells, Cultured

The aggregation-induced emission (AIE) effect has recently been widely applied for biomarker sensing. But developing “smart” strategies to effectively aggregate the AIE fluorogen and additionally enhance the fluorescence emission remain challenging. In this work, by integrating a biocompatible conde...