Dual aggregation-induced emission for enhanced fluorescence sensing of furin activity in vitro and in living cells
The aggregation-induced emission (AIE) effect has recently been widely applied for biomarker sensing. But developing “smart” strategies to effectively aggregate the AIE fluorogen and additionally enhance the fluorescence emission remain challenging. In this work, by integrating a biocompatible conde...
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| Published in | Chemical communications (Cambridge, England) Vol. 53; no. 6; pp. 1037 - 1040 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
2017
|
| Subjects | |
| Online Access | Get full text |
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| Abstract | The aggregation-induced emission (AIE) effect has recently been widely applied for biomarker sensing. But developing “smart” strategies to effectively aggregate the AIE fluorogen and additionally enhance the fluorescence emission remain challenging. In this work, by integrating a biocompatible condensation reaction with an AIE fluorogen, we rationally designed a “smart” dual AIE probe Ac-Arg-Val-Arg-Arg-Cys(StBu)-Lys(TPE)-CBT (
1
) for enhanced fluorescence sensing furin activity
in vitro
and in living cells. Compared with the single AIE probe Ac-Arg-Val-Arg-Arg-Lys(TPE)-OH (
1-Ctrl
) which also subjects to furin cleavage, fluorescence emissions of
1
were additionally enhanced 1.7 fold and 3.4 fold
in vitro
and in living cells, respectively. We envision that, in the near future, our “smart” strategy of enzyme-instructed dual AIE could be widely applied for sensing (or imaging) enzyme activity
in vitro
and even
in vivo
with dramatically enhanced sensitivity. |
|---|---|
| AbstractList | The aggregation-induced emission (AIE) effect has recently been widely applied for biomarker sensing. But developing "smart" strategies to effectively aggregate the AIE fluorogen and additionally enhance the fluorescence emission remain challenging. In this work, by integrating a biocompatible condensation reaction with an AIE fluorogen, we rationally designed a "smart" dual AIE probe Ac-Arg-Val-Arg-Arg-Cys(StBu)-Lys(TPE)-CBT (1) for enhanced fluorescence sensing furin activity in vitro and in living cells. Compared with the single AIE probe Ac-Arg-Val-Arg-Arg-Lys(TPE)-OH (1-Ctrl) which also subjects to furin cleavage, fluorescence emissions of 1 were additionally enhanced 1.7 fold and 3.4 fold in vitro and in living cells, respectively. We envision that, in the near future, our "smart" strategy of enzyme-instructed dual AIE could be widely applied for sensing (or imaging) enzyme activity in vitro and even in vivo with dramatically enhanced sensitivity. The aggregation-induced emission (AIE) effect has recently been widely applied for biomarker sensing. But developing “smart” strategies to effectively aggregate the AIE fluorogen and additionally enhance the fluorescence emission remain challenging. In this work, by integrating a biocompatible condensation reaction with an AIE fluorogen, we rationally designed a “smart” dual AIE probe Ac-Arg-Val-Arg-Arg-Cys(StBu)-Lys(TPE)-CBT ( 1 ) for enhanced fluorescence sensing furin activity in vitro and in living cells. Compared with the single AIE probe Ac-Arg-Val-Arg-Arg-Lys(TPE)-OH ( 1-Ctrl ) which also subjects to furin cleavage, fluorescence emissions of 1 were additionally enhanced 1.7 fold and 3.4 fold in vitro and in living cells, respectively. We envision that, in the near future, our “smart” strategy of enzyme-instructed dual AIE could be widely applied for sensing (or imaging) enzyme activity in vitro and even in vivo with dramatically enhanced sensitivity. The aggregation-induced emission (AIE) effect has recently been widely applied for biomarker sensing. But developing "smart" strategies to effectively aggregate the AIE fluorogen and additionally enhance the fluorescence emission remain challenging. In this work, by integrating a biocompatible condensation reaction with an AIE fluorogen, we rationally designed a "smart" dual AIE probe Ac-Arg-Val-Arg-Arg-Cys(StBu)-Lys(TPE)-CBT (1) for enhanced fluorescence sensing furin activity in vitro and in living cells. Compared with the single AIE probe Ac-Arg-Val-Arg-Arg-Lys(TPE)-OH (1-Ctrl) which also subjects to furin cleavage, fluorescence emissions of 1 were additionally enhanced 1.7 fold and 3.4 fold in vitro and in living cells, respectively. We envision that, in the near future, our "smart" strategy of enzyme-instructed dual AIE could be widely applied for sensing (or imaging) enzyme activity in vitro and even in vivo with dramatically enhanced sensitivity.The aggregation-induced emission (AIE) effect has recently been widely applied for biomarker sensing. But developing "smart" strategies to effectively aggregate the AIE fluorogen and additionally enhance the fluorescence emission remain challenging. In this work, by integrating a biocompatible condensation reaction with an AIE fluorogen, we rationally designed a "smart" dual AIE probe Ac-Arg-Val-Arg-Arg-Cys(StBu)-Lys(TPE)-CBT (1) for enhanced fluorescence sensing furin activity in vitro and in living cells. Compared with the single AIE probe Ac-Arg-Val-Arg-Arg-Lys(TPE)-OH (1-Ctrl) which also subjects to furin cleavage, fluorescence emissions of 1 were additionally enhanced 1.7 fold and 3.4 fold in vitro and in living cells, respectively. We envision that, in the near future, our "smart" strategy of enzyme-instructed dual AIE could be widely applied for sensing (or imaging) enzyme activity in vitro and even in vivo with dramatically enhanced sensitivity. |
| Author | Liang, Gaolin Liu, Xiaomei |
| Author_xml | – sequence: 1 givenname: Xiaomei surname: Liu fullname: Liu, Xiaomei organization: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, China – sequence: 2 givenname: Gaolin orcidid: 0000-0002-6159-9999 surname: Liang fullname: Liang, Gaolin organization: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28000813$$D View this record in MEDLINE/PubMed |
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| Snippet | The aggregation-induced emission (AIE) effect has recently been widely applied for biomarker sensing. But developing “smart” strategies to effectively... The aggregation-induced emission (AIE) effect has recently been widely applied for biomarker sensing. But developing "smart" strategies to effectively... |
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| SubjectTerms | Biomarkers Cell Survival Cells (biology) chemical compounds Condensation condensation reactions Detection Emission emissions enzyme activity Fluorescence Fluorescent Dyes - chemistry Furin - analysis Furin - metabolism Humans image analysis In Vitro Techniques In vitro testing Molecular Structure Optical Imaging Strategy Tumor Cells, Cultured |
| Title | Dual aggregation-induced emission for enhanced fluorescence sensing of furin activity in vitro and in living cells |
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