Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19 - Li, Zhenhua; Wang, Zhenzhen; Dinh, Phuong-Uyen C.; Zhu, Dashuai; Popowski, Kristen D.; Lutz, Halle; Hu, Shiqi; Lewis, Mark G.; Cook, Anthony; Andersen, Hanne; Greenhouse, Jack; Pessaint, Laurent; et al. (Nature nanotechnology, 2021)
Keywords: 631/61/350/2093; 631/61/54/152; ACE2; Administration, Inhalation; Angiotensin; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - metabolism; Animal models; Animals; Antiviral drugs; Cell membranes; Cell-Derived Microparticles - metabolism; Cell-Derived Microparticles - transplantation; Chemical compounds; Chemistry and Materials Science; Conversion; Coronaviruses; COVID-19; COVID-19 - virology; COVID-19 Drug Treatment; Disease Models, Animal; Enzymes; Humans; Inhalation; Injury prevention; Lung Injury - prevention & control; Lung Injury - virology; Lungs; Macaca fascicularis; Materials Science; Mice; Mimicry; Nanostructures - administration & dosage; Nanotechnology; Nanotechnology and Microengineering; Pandemics; Pathogenesis; Peptidyl-dipeptidase A; Pharmacology; Primates; Protein Binding; Respiration; SARS-CoV-2 - drug effects; SARS-CoV-2 - metabolism; Severe acute respiratory syndrome coronavirus 2; Spheroids, Cellular - metabolism; Spike Glycoprotein, Coronavirus - metabolism; Spike protein; Toxicity; Viral diseases; Viral Load - drug effects