Catalpol ameliorates endothelial dysfunction and inflammation in diabetic nephropathy via suppression of RAGE/RhoA/ROCK signaling pathway

• Published in: Chemico-biological interactions Vol. 348; p. 109625
• Main Authors: Shu, Anmei, Du, Qiu, Chen, Jing, Gao, Yuyan, Zhu, Yihui, Lv, Gaohong, Lu, Jinfu, Chen, Yuping, Xu, Huiqin
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.10.2021
• Subjects: AGEs; Animals; Catalpol; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - metabolism; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Diabetic nephropathy; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Endothelial dysfunction; Glycation End Products, Advanced - metabolism; Inflammation; Inflammation - drug therapy; Inflammation - metabolism; Iridoid Glucosides - pharmacology; Iridoid Glucosides - therapeutic use; Male; Mice; Mice, Inbred C57BL; RAGE/RhoA/ROCK pathway; Receptor for Advanced Glycation End Products - metabolism; rho-Associated Kinases - metabolism; rhoA GTP-Binding Protein - metabolism; Signal Transduction - drug effects; Endothelial dysfunction; Diabetic nephropathy; Inflammation; AGEs; Catalpol; RAGE/RhoA/ROCK pathway

Catalpol is an iridoid glycoside compound isolated from the root of Rehmannia glutinosa, which has been reported to be a promising candidate for the treatment of diabetic diseases. The present study aimed at investigating the effects and potential mechanism of catalpol on endothelial dysfunction and...