Circular RNAs in osteosarcoma: An update of recent studies (Review)

• Published in: International journal of oncology Vol. 63; no. 5; p. 1
• Main Authors: Zeng, Le, Liu, Longzhou, Ni, Wen-Juan, Xie, Fuhua, Leng, Xiao-Min
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.11.2023; Spandidos Publications UK Ltd
• Subjects: Adolescent; Analysis; Biosynthesis; Bone cancer; Bone Neoplasms - genetics; Cancer; Cell cycle; Chemotherapy; Child; Development and progression; Enzymes; Gene expression; Genes; Genetic transcription; Genetic translation; Humans; Kinases; Medical prognosis; Metastasis; MicroRNA; MicroRNAs; MicroRNAs - genetics; Osteosarcoma; Osteosarcoma - genetics; Pathogenesis; Peptides; Phosphate esters; Phosphatidylinositol 3-Kinases; Proteins; RNA, Circular - genetics; Sarcoma; Transfer RNA; circRNAs; miRNA sponge; biomarker; osteosarcoma

Osteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic ability, resistance to chemotherapy, and a low 5‑year survival rate, the diagnosis and treatment of OS post a global healthy issue. Over the...