Circular RNAs in osteosarcoma: An update of recent studies (Review)

Osteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic ability, resistance to chemotherapy, and a low 5‑year survival rate, the diagnosis and treatment of OS post a global healthy issue. Over the...

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Published inInternational journal of oncology Vol. 63; no. 5; p. 1
Main Authors Zeng, Le, Liu, Longzhou, Ni, Wen-Juan, Xie, Fuhua, Leng, Xiao-Min
Format Journal Article
LanguageEnglish
Published Greece Spandidos Publications 01.11.2023
Spandidos Publications UK Ltd
Subjects
Adolescent
Analysis
Biosynthesis
Bone cancer
Bone Neoplasms - genetics
Cancer
Cell cycle
Chemotherapy
Child
Development and progression
Enzymes
Gene expression
Genes
Genetic transcription
Genetic translation
Humans
Kinases
Medical prognosis
Metastasis
MicroRNA
MicroRNAs
MicroRNAs - genetics
Osteosarcoma
Osteosarcoma - genetics
Pathogenesis
Peptides
Phosphate esters
Phosphatidylinositol 3-Kinases
Proteins
RNA, Circular - genetics
Sarcoma
Transfer RNA
circRNAs
miRNA sponge
biomarker
osteosarcoma
Online AccessGet full text
ISSN1019-6439
1791-2423
DOI10.3892/ijo.2023.5571

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Abstract Osteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic ability, resistance to chemotherapy, and a low 5‑year survival rate, the diagnosis and treatment of OS post a global healthy issue. Over the past decades, RNA biology has shed new light onto the pathogenesis of OS. As a type of non‑coding RNAs, circular RNAs (circRNAs) have been found to play crucial roles in cellular activities. Recently, a large number of circRNAs have been identified in OS and some of them have been validated to be functional in OS. In the present review, abnormally expressed and different types of circRNAs in OS are summarized. Functional studies on circRNAs have revealed that circRNAs can regulate gene expression at different levels, such as gene transcription, precursor mRNA splicing, miRNA sponges and translation into proteins/peptides. Mechanistic analyses on circRNAs show that circRNAs can regulate JAK‑STAT3, NF‑κB, PI3K‑AKT, Wnt/β‑catenin signaling pathways during the occurrence and development of OS. Furthermore, the potential clinical applications of circRNAs are also emphasized. The present review focus on the current knowledge on the functions and mechanisms of circRNAs in the pathogenesis of OS, aiming to provide new insight into the OS diagnosis and treatment of OS.
AbstractList Osteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic ability, resistance to chemotherapy, and a low 5-year survival rate, the diagnosis and treatment of OS post a global healthy issue. Over the past decades, RNA biology has shed new light onto the pathogenesis of OS. As a type of non-coding RNAs, circular RNAs (circRNAs) have been found to play crucial roles in cellular activities. Recently, a large number of circRNAs have been identified in OS and some of them have been validated to be functional in OS. In the present review, abnormally expressed and different types of circRNAs in OS are summarized. Functional studies on circRNAs have revealed that circRNAs can regulate gene expression at different levels, such as gene transcription, precursor mRNA splicing, miRNA sponges and translation into proteins/peptides. Mechanistic analyses on circRNAs show that circRNAs can regulate JAK-STAT3, NF-κB, PI3K-AKT, Wnt/β-catenin signaling pathways during the occurrence and development of OS. Furthermore, the potential clinical applications of circRNAs are also emphasized. The present review focus on the current knowledge on the functions and mechanisms of circRNAs in the pathogenesis of OS, aiming to provide new insight into the OS diagnosis and treatment of OS.
Osteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic ability, resistance to chemotherapy, and a low 5-year survival rate, the diagnosis and treatment of OS post a global healthy issue. Over the past decades, RNA biology has shed new light onto the pathogenesis of OS. As a type of non-coding RNAs, circular RNAs (circRNAs) have been found to play crucial roles in cellular activities. Recently, a large number of circRNAs have been identified in OS and some of them have been validated to be functional in OS. In the present review, abnormally expressed and different types of circRNAs in OS are summarized. Functional studies on circRNAs have revealed that circRNAs can regulate gene expression at different levels, such as gene transcription, precursor mRNA splicing, miRNA sponges and translation into proteins/peptides. Mechanistic analyses on circRNAs show that circRNAs can regulate JAK-STAT3, NF-[kappa]B, PI3K-AKT, Wnt/[beta]-catenin signaling pathways during the occurrence and development of OS. Furthermore, the potential clinical applications of circRNAs are also emphasized. The present review focus on the current knowledge on the functions and mechanisms of circRNAs in the pathogenesis of OS, aiming to provide new insight into the OS diagnosis and treatment of OS. Key words: circRNAs, miRNA sponge, osteosarcoma, biomarker
Osteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic ability, resistance to chemotherapy, and a low 5-year survival rate, the diagnosis and treatment of OS post a global healthy issue. Over the past decades, RNA biology has shed new light onto the pathogenesis of OS. As a type of non-coding RNAs, circular RNAs (circRNAs) have been found to play crucial roles in cellular activities. Recently, a large number of circRNAs have been identified in OS and some of them have been validated to be functional in OS. In the present review, abnormally expressed and different types of circRNAs in OS are summarized. Functional studies on circRNAs have revealed that circRNAs can regulate gene expression at different levels, such as gene transcription, precursor mRNA splicing, miRNA sponges and translation into proteins/peptides. Mechanistic analyses on circRNAs show that circRNAs can regulate JAK-STAT3, NF-[kappa]B, PI3K-AKT, Wnt/[beta]-catenin signaling pathways during the occurrence and development of OS. Furthermore, the potential clinical applications of circRNAs are also emphasized. The present review focus on the current knowledge on the functions and mechanisms of circRNAs in the pathogenesis of OS, aiming to provide new insight into the OS diagnosis and treatment of OS.
ArticleNumber 123
Audience Academic
Author Liu, Longzhou
Xie, Fuhua
Zeng, Le
Ni, Wen-Juan
Leng, Xiao-Min
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Snippet Osteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic...
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SubjectTerms Adolescent
Analysis
Biosynthesis
Bone cancer
Bone Neoplasms - genetics
Cancer
Cell cycle
Chemotherapy
Child
Development and progression
Enzymes
Gene expression
Genes
Genetic transcription
Genetic translation
Humans
Kinases
Medical prognosis
Metastasis
MicroRNA
MicroRNAs
MicroRNAs - genetics
Osteosarcoma
Osteosarcoma - genetics
Pathogenesis
Peptides
Phosphate esters
Phosphatidylinositol 3-Kinases
Proteins
RNA, Circular - genetics
Sarcoma
Transfer RNA
Title Circular RNAs in osteosarcoma: An update of recent studies (Review)
URI https://www.ncbi.nlm.nih.gov/pubmed/37681483
https://www.proquest.com/docview/2885118343
Volume 63
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