A single-cell atlas reveals the heterogeneity of meningeal immunity in a mouse model of Methyl CpG binding protein 2 deficiency

• Published in: Frontiers in immunology Vol. 13; p. 1056447
• Main Authors: Li, Huiping, Hu, Meixin, Huang, Zhuxi, Wang, Yi, Xu, Ying, Deng, Jingxin, Zhu, Ming, Feng, Weijun, Xu, Xiu
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.01.2023
• Subjects: Animals; CD8-Positive T-Lymphocytes - metabolism; central nervous system; Immunology; meningeal immunity; Meninges - metabolism; methyl CpG binding protein 2; Methyl-CpG-Binding Protein 2 - genetics; Methyl-CpG-Binding Protein 2 - metabolism; Mice; Mice, Knockout; mouse model; Rett syndrome; Rett Syndrome - genetics; Rett Syndrome - metabolism; single-cell analysis; meningeal immunity; mouse model; methyl CpG binding protein 2; Rett syndrome; central nervous system; single-cell analysis

Methyl CpG binding protein 2 (MeCP2) is a DNA methylation reader protein. Mutations in are the major cause of Rett syndrome (RTT). Increasing evidence has shown that dysregulated immunity and chronic subclinical inflammation are linked to MeCP2 deficiency and contribute to RTT development and deteri...