A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination

• Published in: Nature nanotechnology Vol. 17; no. 9; pp. 993 - 1003
• Main Authors: Zhang, Guofang, Cong, Yalin, Liu, Feng-Liang, Sun, Jiufeng, Zhang, Jiantian, Cao, Guoli, Zhou, Lingqiang, Yang, Wenjie, Song, Qingle, Wang, Fangjun, Liu, Ke, Qu, Jing, Wang, Jing, He, Min, Feng, Shun, Baimanov, Didar, Xu, Wei, Luo, Rong-Hua, Long, Xin-Yan, Liao, Shumin, Fan, Yunping, Li, Yu-Feng, Li, Bai, Shao, Ximing, Wang, Guocheng, Fang, Lijing, Wang, Huaiyu, Yu, Xue-Feng, Chang, Yan-Zhong, Zhao, Yuliang, Li, Liang, Yu, Peng, Zheng, Yong-Tang, Boraschi, Diana, Li, Hongchang, Chen, Chunying, Wang, Liming, Li, Yang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2022; Nature Publishing Group
• Subjects: 631/326/596/4130; 639/301/357/1018; ACE2; Angiotensin; Angiotensin-Converting Enzyme 2; Animal models; Animals; Biocompatibility; Chemistry and Materials Science; Coronaviruses; COVID-19; COVID-19 Drug Treatment; Decontamination; Humans; Infections; Infectivity; Macrophages; Materials Science; Mice; Nanomaterials; Nanostructures - therapeutic use; Nanotechnology; Nanotechnology and Microengineering; Organoids; Pandemics; Peptidyl-dipeptidase A; Protein Binding; Proteins; Respiratory diseases; SARS-CoV-2; Selective binding; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - metabolism; Spike protein; Transgenic mice; Viral diseases; Viral infections; Viruses

The global emergency caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic can only be solved with effective and widespread preventive and therapeutic strategies, and both are still insufficient. Here, we describe an ultrathin two-dimensional CuInP 2 S 6 (CIPS) nanoshee...