A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination

The global emergency caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic can only be solved with effective and widespread preventive and therapeutic strategies, and both are still insufficient. Here, we describe an ultrathin two-dimensional CuInP 2 S 6 (CIPS) nanoshee...

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Published inNature nanotechnology Vol. 17; no. 9; pp. 993 - 1003
Main Authors Zhang, Guofang, Cong, Yalin, Liu, Feng-Liang, Sun, Jiufeng, Zhang, Jiantian, Cao, Guoli, Zhou, Lingqiang, Yang, Wenjie, Song, Qingle, Wang, Fangjun, Liu, Ke, Qu, Jing, Wang, Jing, He, Min, Feng, Shun, Baimanov, Didar, Xu, Wei, Luo, Rong-Hua, Long, Xin-Yan, Liao, Shumin, Fan, Yunping, Li, Yu-Feng, Li, Bai, Shao, Ximing, Wang, Guocheng, Fang, Lijing, Wang, Huaiyu, Yu, Xue-Feng, Chang, Yan-Zhong, Zhao, Yuliang, Li, Liang, Yu, Peng, Zheng, Yong-Tang, Boraschi, Diana, Li, Hongchang, Chen, Chunying, Wang, Liming, Li, Yang
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.09.2022
Nature Publishing Group
Subjects
631/326/596/4130
639/301/357/1018
ACE2
Angiotensin
Angiotensin-Converting Enzyme 2
Animal models
Animals
Biocompatibility
Chemistry and Materials Science
Coronaviruses
COVID-19
COVID-19 Drug Treatment
Decontamination
Humans
Infections
Infectivity
Macrophages
Materials Science
Mice
Nanomaterials
Nanostructures - therapeutic use
Nanotechnology
Nanotechnology and Microengineering
Organoids
Pandemics
Peptidyl-dipeptidase A
Protein Binding
Proteins
Respiratory diseases
SARS-CoV-2
Selective binding
Severe acute respiratory syndrome coronavirus 2
Spike Glycoprotein, Coronavirus - genetics
Spike Glycoprotein, Coronavirus - metabolism
Spike protein
Transgenic mice
Viral diseases
Viral infections
Viruses
Online AccessGet full text

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Abstract The global emergency caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic can only be solved with effective and widespread preventive and therapeutic strategies, and both are still insufficient. Here, we describe an ultrathin two-dimensional CuInP 2 S 6 (CIPS) nanosheet as a new agent against SARS-CoV-2 infection. CIPS exhibits an extremely high and selective binding capacity (dissociation constant ( K D ) < 1 pM) for the receptor binding domain of the spike protein of wild-type SARS-CoV-2 and its variants of concern, including Delta and Omicron, inhibiting virus entry and infection in angiotensin converting enzyme 2 (ACE2)-bearing cells, human airway epithelial organoids and human ACE2-transgenic mice. On association with CIPS, the virus is quickly phagocytosed and eliminated by macrophages, suggesting that CIPS could be successfully used to capture and facilitate virus elimination by the host. Thus, we propose CIPS as a promising nanodrug for future safe and effective anti-SARS-CoV-2 therapy, and as a decontamination agent and surface-coating material to reduce SARS-CoV-2 infectivity. While vaccines have curbed the COVID-19 pandemic, effective therapeutic treatments are few, and might be challenged by SARS-CoV-2 variants. A biocompatible, antiviral two-dimensional nanomaterial is now reported that firmly adsorbs the virus by interaction with the spike protein, inducing the conformational changes that lead to inhibition of viral infection in vitro and in animal models.
AbstractList The global emergency caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic can only be solved with effective and widespread preventive and therapeutic strategies, and both are still insufficient. Here, we describe an ultrathin two-dimensional CuInP S (CIPS) nanosheet as a new agent against SARS-CoV-2 infection. CIPS exhibits an extremely high and selective binding capacity (dissociation constant (K ) < 1 pM) for the receptor binding domain of the spike protein of wild-type SARS-CoV-2 and its variants of concern, including Delta and Omicron, inhibiting virus entry and infection in angiotensin converting enzyme 2 (ACE2)-bearing cells, human airway epithelial organoids and human ACE2-transgenic mice. On association with CIPS, the virus is quickly phagocytosed and eliminated by macrophages, suggesting that CIPS could be successfully used to capture and facilitate virus elimination by the host. Thus, we propose CIPS as a promising nanodrug for future safe and effective anti-SARS-CoV-2 therapy, and as a decontamination agent and surface-coating material to reduce SARS-CoV-2 infectivity.
The global emergency caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic can only be solved with effective and widespread preventive and therapeutic strategies, and both are still insufficient. Here, we describe an ultrathin two-dimensional CuInP 2 S 6 (CIPS) nanosheet as a new agent against SARS-CoV-2 infection. CIPS exhibits an extremely high and selective binding capacity (dissociation constant ( K D ) < 1 pM) for the receptor binding domain of the spike protein of wild-type SARS-CoV-2 and its variants of concern, including Delta and Omicron, inhibiting virus entry and infection in angiotensin converting enzyme 2 (ACE2)-bearing cells, human airway epithelial organoids and human ACE2-transgenic mice. On association with CIPS, the virus is quickly phagocytosed and eliminated by macrophages, suggesting that CIPS could be successfully used to capture and facilitate virus elimination by the host. Thus, we propose CIPS as a promising nanodrug for future safe and effective anti-SARS-CoV-2 therapy, and as a decontamination agent and surface-coating material to reduce SARS-CoV-2 infectivity. While vaccines have curbed the COVID-19 pandemic, effective therapeutic treatments are few, and might be challenged by SARS-CoV-2 variants. A biocompatible, antiviral two-dimensional nanomaterial is now reported that firmly adsorbs the virus by interaction with the spike protein, inducing the conformational changes that lead to inhibition of viral infection in vitro and in animal models.
The global emergency caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic can only be solved with effective and widespread preventive and therapeutic strategies, and both are still insufficient. Here, we describe an ultrathin two-dimensional CuInP2S6 (CIPS) nanosheet as a new agent against SARS-CoV-2 infection. CIPS exhibits an extremely high and selective binding capacity (dissociation constant (KD) < 1 pM) for the receptor binding domain of the spike protein of wild-type SARS-CoV-2 and its variants of concern, including Delta and Omicron, inhibiting virus entry and infection in angiotensin converting enzyme 2 (ACE2)-bearing cells, human airway epithelial organoids and human ACE2-transgenic mice. On association with CIPS, the virus is quickly phagocytosed and eliminated by macrophages, suggesting that CIPS could be successfully used to capture and facilitate virus elimination by the host. Thus, we propose CIPS as a promising nanodrug for future safe and effective anti-SARS-CoV-2 therapy, and as a decontamination agent and surface-coating material to reduce SARS-CoV-2 infectivity.While vaccines have curbed the COVID-19 pandemic, effective therapeutic treatments are few, and might be challenged by SARS-CoV-2 variants. A biocompatible, antiviral two-dimensional nanomaterial is now reported that firmly adsorbs the virus by interaction with the spike protein, inducing the conformational changes that lead to inhibition of viral infection in vitro and in animal models.
Author Yu, Peng
Boraschi, Diana
Zhou, Lingqiang
Yu, Xue-Feng
Cao, Guoli
Xu, Wei
Wang, Liming
Zheng, Yong-Tang
He, Min
Li, Liang
Zhang, Jiantian
Song, Qingle
Shao, Ximing
Wang, Huaiyu
Chang, Yan-Zhong
Zhang, Guofang
Baimanov, Didar
Luo, Rong-Hua
Li, Yu-Feng
Qu, Jing
Cong, Yalin
Liao, Shumin
Zhao, Yuliang
Liu, Feng-Liang
Wang, Guocheng
Fang, Lijing
Liu, Ke
Wang, Jing
Feng, Shun
Yang, Wenjie
Wang, Fangjun
Li, Hongchang
Chen, Chunying
Fan, Yunping
Li, Bai
Li, Yang
Long, Xin-Yan
Sun, Jiufeng
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35995853$$D View this record in MEDLINE/PubMed
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Snippet The global emergency caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic can only be solved with effective and widespread...
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SubjectTerms 631/326/596/4130
639/301/357/1018
ACE2
Angiotensin
Angiotensin-Converting Enzyme 2
Animal models
Animals
Biocompatibility
Chemistry and Materials Science
Coronaviruses
COVID-19
COVID-19 Drug Treatment
Decontamination
Humans
Infections
Infectivity
Macrophages
Materials Science
Mice
Nanomaterials
Nanostructures - therapeutic use
Nanotechnology
Nanotechnology and Microengineering
Organoids
Pandemics
Peptidyl-dipeptidase A
Protein Binding
Proteins
Respiratory diseases
SARS-CoV-2
Selective binding
Severe acute respiratory syndrome coronavirus 2
Spike Glycoprotein, Coronavirus - genetics
Spike Glycoprotein, Coronavirus - metabolism
Spike protein
Transgenic mice
Viral diseases
Viral infections
Viruses
Title A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination
URI https://link.springer.com/article/10.1038/s41565-022-01177-2
https://www.ncbi.nlm.nih.gov/pubmed/35995853
https://www.proquest.com/docview/2714789255
Volume 17
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