Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway - Wang, Kai; Lv, Qi; Miao, Yu-meng; Qiao, Si-miao; Dai, Yue; Wei, Zhi-feng (Biochemical pharmacology, 2018)
Keywords: Animals; Aryl hydrocarbon receptor; Cardamonin; Cell Survival - drug effects; Cell Survival - physiology; Chalcones - pharmacology; Chalcones - therapeutic use; Dose-Response Relationship, Drug; Flavones - pharmacology; Flavones - therapeutic use; Inflammatory bowel disease; Inflammatory Bowel Diseases - drug therapy; Inflammatory Bowel Diseases - metabolism; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone) - metabolism; NF-E2-Related Factor 2 - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLRP3 inflammasome; Receptors, Aryl Hydrocarbon - metabolism; Signal Transduction - drug effects; Signal Transduction - physiology; TCDD; HO-1; IBD; XRE; BMDM; NLRP3 inflammasome; MPO; LPS; UC; Caspase-1; ASC; BSA; DMEM; Nrf2; EMSA; FBS; NLRP3; HPLC; PBS; CD; HSP90; NQO1; DSS; Pro-IL-1β; ARNT; AhR; IL-1β; SOD2; TNBS; DAI; IL-6; Trx1; Inflammatory bowel disease; Aryl hydrocarbon receptor; TNF-α; Cardamonin; ROS; CYP1A1; Keap1; ATP; ELISA; Pro-IL-18