Involvement of CREB3L1 in erythropoiesis induced by JAK2 exon 12 mutation

• Published in: Experimental hematology Vol. 139; p. 104636
• Main Authors: Okuda, Maho, Araki, Marito, De Marchi, Federico, Morishita, Soji, Imai, Misa, Fukada, Hanaka, Ando, Miki, Komatsu, Norio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.11.2024
• Subjects: Advanced Basic Science; Hematology, Oncology, and Palliative Medicine

•CREB3L1 expression in RBCs discriminates JAK2 exon12 and V617F mutations.•CREB3L1 is required for the erythrocytosis associated with EPOR hyperactivation.•CREB3L1 may be a potential therapeutic target for MPN. [Display omitted] CREB3L1, a gene encoding the endoplasmic reticulum stress transducer, i...