The use of drug provocation testing in the investigation of suspected immediate perioperative allergic reactions: current status

• Published in: British journal of anaesthesia : BJA Vol. 123; no. 1; pp. e126 - e134
• Main Authors: Garvey, Lene H., Ebo, Didier G., Krøigaard, Mogens, Savic, Sinisa, Clarke, Russell, Cooke, Peter, Dewachter, Pascale, Garcez, Tomaz, Guttormsen, Anne B., Hopkins, Philip M., Hepner, David L., Khan, David A., Kolawole, Helen, Kopac, Peter, Marshall, Stuart, Mertes, Paul-Michel, Platt, Peter, Rose, Michael, Sabato, Vito, Sadleir, Paul, Savic, Louise, Scherer, Kathrin, Takazawa, Tomonori, Volcheck, Gerald W., Voltolini, Susanna, Laguna, Jose J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2019
• Subjects: allergy; anaphylaxis; challenge testing; drug hypersensitivity; drug provocation test; perioperative period; challenge testing; allergy; anaphylaxis; perioperative period; drug provocation test; drug hypersensitivity

Suspected perioperative allergic reactions are often severe. To avoid potentially life-threatening re-exposure to the culprit drug, establishing a firm diagnosis and identifying the culprit is crucial. Drug provocation tests are considered the gold standard in drug allergy investigation but have not...