Albumin as a versatile platform for drug half-life extension

• Published in: Biochimica et biophysica acta Vol. 1830; no. 12; pp. 5526 - 5534
• Main Authors: Sleep, Darrell, Cameron, Jason, Evans, Leslie R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2013
• Subjects: Albumin; Animal models; Animals; drugs; FcRn; filtration; Half-Life; Humans; Immunoglobulin G - metabolism; patient compliance; Pharmacokinetics; Protein drug; Receptors, Fc - metabolism; serum albumin; Serum Albumin - metabolism; Albumin; FcRn; Animal models; Half-life; Protein drug; Pharmacokinetics

Albumin is the most abundant plasma protein, is highly soluble, very stable and has an extraordinarily long circulatory half-life as a direct result of its size and interaction with the FcRn mediated recycling pathway. In contrast, many therapeutic molecules are smaller than the renal filtration thr...