Complementary hydrogen bonding interaction triggered co-assembly of an amphiphilic peptide and an anti-tumor drug

• Published in: Chemical communications (Cambridge, England) Vol. 51; no. 32; pp. 6936 - 6939
• Main Authors: Cheng, Hong, Cheng, Yin-Jia, Bhasin, Sushant, Zhu, Jing-Yi, Xu, Xiao-Ding, Zhuo, Ren-Xi, Zhang, Xian-Zheng
• Format: Journal Article
• Language: English
• Published: England 25.04.2015
• Subjects: Animals; Antineoplastic Agents - chemistry; Cercopithecus aethiops; chemical reactions; COS Cells; cytotoxicity; Drugs; HeLa Cells; Humans; Hydrogen Bonding; Hydrogen bonds; Hydrophobic and Hydrophilic Interactions; inhibitory concentration 50; Methotrexate; Methotrexate - chemistry; micelles; Models, Molecular; Molecular Conformation; Nanofibers; Nanofibers - chemistry; Nanorods; neoplasm cells; Peptides; Peptides - chemistry; Toxicity

We report a new tumor-targeting amphiphilic peptide that can form complementary hydrogen bonds with anti-tumor drug methotrexate (MTX), leading to reversible self-assembled morphology transition from loose micelles to densely packed nanorods or nanofibers. The MTX loaded nanorods can target tumor ce...