Resveratrol induces cell death and inhibits human herpesvirus 8 replication in primary effusion lymphoma cells

• Published in: Chemico-biological interactions Vol. 242; pp. 372 - 379
• Main Authors: Tang, Feng-Yi, Chen, Chang-Yu, Shyu, Huey-Wen, Hong, Shin, Chen, Hung-Ming, Chiou, Yee-Hsuan, Lin, Kuan-Hua, Chou, Miao-Chen, Wang, Lin-Yu, Wang, Yi-Fen
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 05.12.2015
• Subjects: Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy - drug effects; CASP8 and FADD-Like Apoptosis Regulating Protein - genetics; Caspase 3 - metabolism; Cell Line, Tumor; Cell Proliferation - drug effects; Enzyme Activation - drug effects; Herpesvirus 8, Human - drug effects; Herpesvirus 8, Human - genetics; Herpesvirus 8, Human - physiology; Human herpesvirus 8; Humans; Lymphoma, Primary Effusion - pathology; Lymphoma, Primary Effusion - virology; Primary effusion lymphoma; Reactive Oxygen Species - metabolism; Resveratrol; ROS; Stilbenes - pharmacology; Virus Replication - drug effects; Human herpesvirus 8; Primary effusion lymphoma; Autophagy; Resveratrol; ROS; Apoptosis

Resveratrol (3,4′,5-trihydroxy-trans-stilbene) has been reported to inhibit proliferation of various cancer cells. However, the effects of resveratrol on the human herpesvirus 8 (HHV8) harboring primary effusion lymphoma (PEL) cells remains unclear. The anti-proliferation effects and possible mechan...