Lipotoxicity-induced circGlis3 impairs beta cell function and is transmitted by exosomes to promote islet endothelial cell dysfunction

• Published in: Diabetologia Vol. 65; no. 1; pp. 188 - 205
• Main Authors: Xiong, Li, Chen, Li, Wu, Liting, He, Weiman, Chen, Dubo, Peng, Zishan, Li, Jin, Zhu, Xiaonan, Su, Lei, Li, Yanbing, Gong, Yingying, Xiao, Haipeng
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2022; Springer Nature B.V
• Subjects: Angiogenesis; Animal models; Animals; Beta cells; Cell interactions; Cell migration; Cell viability; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Endothelial cells; Endothelial Cells - metabolism; Exosomes; Exosomes - metabolism; Glucocorticoids; Heat shock proteins; Hsp27 protein; Human Physiology; Humans; Immunoprecipitation; Internal Medicine; Mass spectroscopy; Medicine; Medicine & Public Health; Metabolic Diseases; Mice; Molecular modelling; Nucleotide sequence; Palmitic acid; Phosphorylation; Proteins; Ribonucleic acid; RNA; RNA, Circular - genetics; RNA, Circular - metabolism; Ubiquitin; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - metabolism; Beta cells; Circular RNA; Islet endothelial cells; Diabetes; Lipotoxicity; Exosome

Aims/hypothesis Lipotoxicity constitutes the major driving force for type 2 diabetes. Circular RNAs (circRNAs) play important roles in regulating beta cell function and exosomes are essential mediators of intercellular communication. The role of exosomal circRNAs in type 2 diabetes remains largely u...