Lipotoxicity-induced circGlis3 impairs beta cell function and is transmitted by exosomes to promote islet endothelial cell dysfunction - Xiong, Li; Chen, Li; Wu, Liting; He, Weiman; Chen, Dubo; Peng, Zishan; Li, Jin; Zhu, Xiaonan; Su, Lei; Li, Yanbing; Gong, Yingying; Xiao, Haipeng (Diabetologia, 2022)
Keywords: Angiogenesis; Animal models; Animals; Beta cells; Cell interactions; Cell migration; Cell viability; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Endothelial cells; Endothelial Cells - metabolism; Exosomes; Exosomes - metabolism; Glucocorticoids; Heat shock proteins; Hsp27 protein; Human Physiology; Humans; Immunoprecipitation; Internal Medicine; Mass spectroscopy; Medicine; Medicine & Public Health; Metabolic Diseases; Mice; Molecular modelling; Nucleotide sequence; Palmitic acid; Phosphorylation; Proteins; Ribonucleic acid; RNA; RNA, Circular - genetics; RNA, Circular - metabolism; Ubiquitin; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - metabolism; Beta cells; Circular RNA; Islet endothelial cells; Diabetes; Lipotoxicity; Exosome