Use of Microfluidics to Fabricate Bioerodable Lipid Hybrid Nanoparticles Containing Hydromorphone or Ketamine for the Relief of Intractable Pain

• Published in: Pharmaceutical research Vol. 37; no. 10; p. 211
• Main Authors: Zhu, Minze, Whittaker, Andrew K., Jiang, Xingyu, Tang, Rupei, Li, Xuanyu, Xu, Weizhi, Fu, Changkui, Smith, Maree T, Han, Felicity Y
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2020; Springer; Springer Nature B.V
• Subjects: Analgesia; Analgesics; Analysis; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Care and treatment; Injection; Ion channels; Ketamine; Light scattering; Medical Law; Microfluidics; Nanoparticles; Narcotics; Opioids; Pain; Pain perception; Peripheral neuropathy; Pharmacology/Toxicology; Pharmacy; Polylactide-co-glycolide; Polymers; Research Paper; Transmission electron microscopy; bulk eroding polymers; surface eroding polymers; intrathecal (i.t.) injection; drug delivery; intractable neuropathic pain

Purpose For patients with intractable cancer-related pain, administration of strong opioid analgesics and adjuvant agents by the intrathecal (i.t.) route in close proximity to the target receptors/ion channels, may restore pain relief. Hence, the aim of this study was to use bioerodable polymers to...