Association of blood pressure variability during acute care hospitalization and incident dementia
Recognized as a potential risk factor for Alzheimer's disease and related dementias (ADRD), blood pressure variability (BPV) could be leveraged to facilitate identification of at-risk individuals at a population level. Granular BPV data are available during acute care hospitalization periods fo...
Saved in:
Published in | Frontiers in neurology Vol. 14; p. 1085885 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
07.02.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Recognized as a potential risk factor for Alzheimer's disease and related dementias (ADRD), blood pressure variability (BPV) could be leveraged to facilitate identification of at-risk individuals at a population level. Granular BPV data are available during acute care hospitalization periods for potentially high-risk patients, but the incident ADRD risk association with BPV measured in this setting is unknown. Our objective was to evaluate the relation of BPV, measured during acute care hospitalization, and incidence of ADRD.
We retrospectively studied adults, without a prior ADRD diagnosis, who were admitted to a large quaternary care medical center in Southern California between January 1, 2013 and December 31, 2019. For all patients, determined BPV, calculated as variability independent of the mean (VIM), using blood pressure readings obtained as part of routine clinical care. We used multivariable Cox proportional hazards regression to examine the association between BP VIM during hospitalization and the development of incident dementia, determined by new ICD-9/10 coding or the new prescription of dementia medication, occurring at least 2 years after the index hospitalization.
Of 81,892 adults hospitalized without a prior ADRD diagnosis, 2,442 (2.98%) went on to develop ADRD (2.6 to 5.2 years after hospitalization). In multivariable-adjusted Cox models, both systolic (HR 1.05, 95% CI 1.00-1.09) and diastolic (1.06, 1.02-1.10) VIM were associated with incident ADRD. In pre-specified stratified analyses, the VIM associations with incident ADRD were most pronounced in individuals over age 60 years and among those with renal disease or hypertension. Results were similar when repeated to include incident ADRD diagnoses made at least 1 or 3 years after index hospitalization.
We found that measurements of BPV from acute care hospitalizations can be used to identify individuals at risk for developing a diagnosis of ADRD within approximately 5 years. Use of the readily accessible BPV measure may allow healthcare systems to risk stratify patients during periods of intense patient-provider interaction and, in turn, facilitate engagement in ADRD screening programs. |
---|---|
AbstractList | Background and objectivesRecognized as a potential risk factor for Alzheimer's disease and related dementias (ADRD), blood pressure variability (BPV) could be leveraged to facilitate identification of at-risk individuals at a population level. Granular BPV data are available during acute care hospitalization periods for potentially high-risk patients, but the incident ADRD risk association with BPV measured in this setting is unknown. Our objective was to evaluate the relation of BPV, measured during acute care hospitalization, and incidence of ADRD.MethodsWe retrospectively studied adults, without a prior ADRD diagnosis, who were admitted to a large quaternary care medical center in Southern California between January 1, 2013 and December 31, 2019. For all patients, determined BPV, calculated as variability independent of the mean (VIM), using blood pressure readings obtained as part of routine clinical care. We used multivariable Cox proportional hazards regression to examine the association between BP VIM during hospitalization and the development of incident dementia, determined by new ICD-9/10 coding or the new prescription of dementia medication, occurring at least 2 years after the index hospitalization.ResultsOf 81,892 adults hospitalized without a prior ADRD diagnosis, 2,442 (2.98%) went on to develop ADRD (2.6 to 5.2 years after hospitalization). In multivariable-adjusted Cox models, both systolic (HR 1.05, 95% CI 1.00–1.09) and diastolic (1.06, 1.02–1.10) VIM were associated with incident ADRD. In pre-specified stratified analyses, the VIM associations with incident ADRD were most pronounced in individuals over age 60 years and among those with renal disease or hypertension. Results were similar when repeated to include incident ADRD diagnoses made at least 1 or 3 years after index hospitalization.DiscussionWe found that measurements of BPV from acute care hospitalizations can be used to identify individuals at risk for developing a diagnosis of ADRD within approximately 5 years. Use of the readily accessible BPV measure may allow healthcare systems to risk stratify patients during periods of intense patient-provider interaction and, in turn, facilitate engagement in ADRD screening programs. Recognized as a potential risk factor for Alzheimer's disease and related dementias (ADRD), blood pressure variability (BPV) could be leveraged to facilitate identification of at-risk individuals at a population level. Granular BPV data are available during acute care hospitalization periods for potentially high-risk patients, but the incident ADRD risk association with BPV measured in this setting is unknown. Our objective was to evaluate the relation of BPV, measured during acute care hospitalization, and incidence of ADRD. We retrospectively studied adults, without a prior ADRD diagnosis, who were admitted to a large quaternary care medical center in Southern California between January 1, 2013 and December 31, 2019. For all patients, determined BPV, calculated as variability independent of the mean (VIM), using blood pressure readings obtained as part of routine clinical care. We used multivariable Cox proportional hazards regression to examine the association between BP VIM during hospitalization and the development of incident dementia, determined by new ICD-9/10 coding or the new prescription of dementia medication, occurring at least 2 years after the index hospitalization. Of 81,892 adults hospitalized without a prior ADRD diagnosis, 2,442 (2.98%) went on to develop ADRD (2.6 to 5.2 years after hospitalization). In multivariable-adjusted Cox models, both systolic (HR 1.05, 95% CI 1.00-1.09) and diastolic (1.06, 1.02-1.10) VIM were associated with incident ADRD. In pre-specified stratified analyses, the VIM associations with incident ADRD were most pronounced in individuals over age 60 years and among those with renal disease or hypertension. Results were similar when repeated to include incident ADRD diagnoses made at least 1 or 3 years after index hospitalization. We found that measurements of BPV from acute care hospitalizations can be used to identify individuals at risk for developing a diagnosis of ADRD within approximately 5 years. Use of the readily accessible BPV measure may allow healthcare systems to risk stratify patients during periods of intense patient-provider interaction and, in turn, facilitate engagement in ADRD screening programs. |
Author | Tan, Zaldy S Wang, Minhao Ebinger, Joseph E Botting, Patrick Driver, Matthew P Cheng, Susan |
AuthorAffiliation | 1 Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center , Los Angeles, CA , United States 2 Department of Neurology and Medicine, Cedars-Sinai Medical Center , Los Angeles, CA , United States 3 David Geffen School of Medicine at UCLA , Los Angeles, CA , United States |
AuthorAffiliation_xml | – name: 1 Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center , Los Angeles, CA , United States – name: 2 Department of Neurology and Medicine, Cedars-Sinai Medical Center , Los Angeles, CA , United States – name: 3 David Geffen School of Medicine at UCLA , Los Angeles, CA , United States |
Author_xml | – sequence: 1 givenname: Joseph E surname: Ebinger fullname: Ebinger, Joseph E organization: Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States – sequence: 2 givenname: Matthew P surname: Driver fullname: Driver, Matthew P organization: Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States – sequence: 3 givenname: Patrick surname: Botting fullname: Botting, Patrick organization: Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States – sequence: 4 givenname: Minhao surname: Wang fullname: Wang, Minhao organization: Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States – sequence: 5 givenname: Susan surname: Cheng fullname: Cheng, Susan organization: Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States – sequence: 6 givenname: Zaldy S surname: Tan fullname: Tan, Zaldy S organization: David Geffen School of Medicine at UCLA, Los Angeles, CA, United States |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36824417$$D View this record in MEDLINE/PubMed |
BookMark | eNpVkc1OHDEQhK2IKBDCC-QQzTGX3fh_xpdICCUBCSmX5Gy17fZiNDve2DNI8PQx7ILAB3fL1fXZVn0kR1OekJDPjK6FGMy3OOFS1pxysWZ0UMOg3pETprVccW7U0av-mJzVekvbEsYILT6QY6EHLiXrTwic15p9gjnlqcuxc2POodsVrHUp2N1BSeDSmOb7LiwlTZsO_DJj56GpN7nu0gxjetj7YQpdmnwKOM1dwG0rCT6R9xHGimeHekr-_vzx5-Jydf3719XF-fXKS2bmlXEgndBUA0atg2NBRReROtWjN0pJ2QcqjRRNG6JnigdtYkDR8xhdcOKUXO25IcOt3ZW0hXJvMyT7dJDLxkKZkx_RNqoH7hUYxyX0se0MncJBKN_HgTbW9z1rt7gtBt8-UmB8A32rTOnGbvKdNUYypfsG-HoAlPxvwTrbbaoexxEmzEu1vB8o1b3Uoo3y_agvudaC8eUaRu1j1PYpavsYtT1E3UxfXj_wxfIcrPgPC1er5w |
Cites_doi | 10.1161/CIRCRESAHA.118.313260 10.1111/j.1751-7176.2011.00543.x 10.1111/j.1532-5415.2000.tb02650.x 10.1161/HYPERTENSIONAHA.120.16696 10.1007/s11940-019-0581-2 10.1155/2017/9708413 10.1002/alz.12167 10.1097/HJH.0000000000001197 10.1002/alz.053738 10.5694/j.1326-5377.2008.tb02140.x 10.1161/STROKEAHA.120.030601 10.1186/s12868-018-0465-5 10.1001/jamainternmed.2015.2152 10.1186/s12877-015-0064-6 10.1186/alzrt200 10.1161/HYPERTENSIONAHA.113.01063 10.1161/HYPERTENSIONAHA.119.14033 10.1038/s41598-021-83945-z 10.7326/0003-4819-154-12-201106210-00005 10.3233/JAD-170757 10.1371/journal.pone.0235534 10.1016/j.jalz.2013.05.1777 10.1186/cc11901 10.1001/jama.2017.3090 10.1001/jamacardio.2020.0799 10.1186/s12913-020-05207-4 10.1016/S0140-6736(15)00516-4 10.1001/jamainternmed.2020.5028 10.23889/ijpds.v1i1.100 10.1002/clc.22310 10.3390/ijms23094962 10.1007/s11606-005-0103-7 10.1111/jch.13412 10.1016/j.jns.2011.04.011 10.1038/nrn.2017.48 10.1371/journal.pmed.1002933 10.1186/s12916-020-01578-x 10.1161/HYPERTENSIONAHA.121.17797 10.1016/j.eclinm.2022.101442 10.1002/pds.4669 10.1093/ajh/hpaa119 10.1093/ajh/hpw124 10.1186/s13195-017-0297-z 10.1212/WNL.0000000000007231 10.1001/jamaneurol.2017.1125 10.1161/CIRCULATIONAHA.116.025667 10.1002/hbm.22515 10.1001/jama.2019.10575 10.1001/archneur.64.2.256 10.1038/s41598-022-05384-8 |
ContentType | Journal Article |
Copyright | Copyright © 2023 Ebinger, Driver, Botting, Wang, Cheng and Tan. Copyright © 2023 Ebinger, Driver, Botting, Wang, Cheng and Tan. 2023 Ebinger, Driver, Botting, Wang, Cheng and Tan |
Copyright_xml | – notice: Copyright © 2023 Ebinger, Driver, Botting, Wang, Cheng and Tan. – notice: Copyright © 2023 Ebinger, Driver, Botting, Wang, Cheng and Tan. 2023 Ebinger, Driver, Botting, Wang, Cheng and Tan |
DBID | NPM AAYXX CITATION 7X8 5PM DOA |
DOI | 10.3389/fneur.2023.1085885 |
DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1664-2295 |
EndPage | 1085885 |
ExternalDocumentID | oai_doaj_org_article_e0bca2c5a9b24a7fb241eb5e835c7f80 10_3389_fneur_2023_1085885 36824417 |
Genre | Journal Article |
GrantInformation_xml | – fundername: ; – fundername: ; grantid: K23-HL153888; R01-HL131532 |
GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV DIK E3Z EMOBN F5P GROUPED_DOAJ GX1 HYE IAO IEA IHR IHW IPNFZ KQ8 M48 M~E NPM O5R O5S OK1 P2P PGMZT RIG RNS RPM AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-c419t-9ba4b3606aef66db1d5fbfe0b57ec955447d049436db8fc152d69fde372ffbdb3 |
IEDL.DBID | RPM |
ISSN | 1664-2295 |
IngestDate | Tue Oct 22 14:54:17 EDT 2024 Tue Sep 17 21:31:30 EDT 2024 Fri Oct 25 04:45:21 EDT 2024 Thu Nov 21 22:09:14 EST 2024 Sat Sep 28 08:14:13 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | blood pressure variability dementia hospitalization hypertension risk prediction |
Language | English |
License | Copyright © 2023 Ebinger, Driver, Botting, Wang, Cheng and Tan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c419t-9ba4b3606aef66db1d5fbfe0b57ec955447d049436db8fc152d69fde372ffbdb3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Junhong Zhou, Harvard Medical School, United States; Craig S. Anderson, University of New South Wales, Australia Edited by: Peng Li, Harvard Medical School, United States This article was submitted to Dementia and Neurodegenerative Diseases, a section of the journal Frontiers in Neurology |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941567/ |
PMID | 36824417 |
PQID | 2780067463 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_e0bca2c5a9b24a7fb241eb5e835c7f80 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9941567 proquest_miscellaneous_2780067463 crossref_primary_10_3389_fneur_2023_1085885 pubmed_primary_36824417 |
PublicationCentury | 2000 |
PublicationDate | 2023-02-07 |
PublicationDateYYYYMMDD | 2023-02-07 |
PublicationDate_xml | – month: 02 year: 2023 text: 2023-02-07 day: 07 |
PublicationDecade | 2020 |
PublicationPlace | Switzerland |
PublicationPlace_xml | – name: Switzerland |
PublicationTitle | Frontiers in neurology |
PublicationTitleAlternate | Front Neurol |
PublicationYear | 2023 |
Publisher | Frontiers Media S.A |
Publisher_xml | – name: Frontiers Media S.A |
References | McMillan (B6) 2014; 35 Ma (B18) 2019; 16 Yano (B23) 2016; 30 Tada (B45) 2007; 64 Beard (B27) 2016; 387 Kim (B13) 2021; 11 Powers (B34) 2011; 154 Allan (B41) 2019; 21 Wei (B48) 2020; 20 De Heus (B14) 2021; 78 De Pablo-Fernandez (B43) 2017; 74 McGuinness (B46) 2019; 28 Kisler (B39) 2017; 18 Chambers (B9) 2017; 2017 Fayosse (B49) 2020; 18 Hiteshi AK Li (B36) 2014; 37 Drawz (B31) 2020; 180 Gottesman (B29) 2017; 317 Tsoi (B4) 2015; 175 Oishi (B19) 2017; 136 Jia (B24) 2021; 17 Speechly (B25) 2008; 189 Nwabuo (B22) 2020; 5 Weinstein (B42) 2021; 52 Goldstein (B44) 2011; 310 Iadecola (B30) 2019; 124 Shabir (B38) 2018; 19 Walker (B11) 2019; 322 Guerra (B3) 2012; 16 Burhan (B5) 2013; 5 Martin (B1) 2015; 15 Haidar (B37) 2021; 77 Cannon-Albright (B50) 2019; 92 Gunes (B8) 2022; 23 Kallioinen (B33) 2017; 35 Galvin (B35) 2020; 15 Knopman (B26) 2000; 48 Wilkinson (B47) 2017; 1 Sipilä (B2) 2020; 16 Tang (B32) 2018; 20 Brook (B12) 2011; 13 Alpérovitch (B17) 2014; 10 Ma (B16) 2020; 33 Yoo (B15) 2020; 75 Crous-Bou (B28) 2017; 9 Kim (B7) 2022; 12 Ebinger (B21) 2022; 48 Boustani (B10) 2005; 20 van Middelaar (B20) 2018; 62 Faraco (B40) 2013; 62 |
References_xml | – volume: 124 start-page: 1025 year: 2019 ident: B30 article-title: Neurovascular and cognitive dysfunction in hypertension publication-title: Circ Res. doi: 10.1161/CIRCRESAHA.118.313260 contributor: fullname: Iadecola – volume: 13 start-page: 836 year: 2011 ident: B12 article-title: Environmental hypertensionology the effects of environmental factors on blood pressure in clinical practice and research publication-title: J Clin Hypertens. doi: 10.1111/j.1751-7176.2011.00543.x contributor: fullname: Brook – volume: 48 start-page: 300 year: 2000 ident: B26 article-title: Patterns of care in the early stages of Alzheimer's disease: impediments to timely diagnosis publication-title: J Am Geriatr Soc. doi: 10.1111/j.1532-5415.2000.tb02650.x contributor: fullname: Knopman – volume: 77 start-page: 1169 year: 2021 ident: B37 article-title: Wave reflection at the origin of a first-generation branch artery and target organ protection publication-title: Hypertension. doi: 10.1161/HYPERTENSIONAHA.120.16696 contributor: fullname: Haidar – volume: 21 start-page: 38 year: 2019 ident: B41 article-title: Diagnosis and management of autonomic dysfunction in dementia syndromes publication-title: Curr Treat Options Neurol. doi: 10.1007/s11940-019-0581-2 contributor: fullname: Allan – volume: 2017 start-page: 9708413 year: 2017 ident: B9 article-title: Is dementia screening of apparently healthy individuals justified? publication-title: Adv Prev Med. doi: 10.1155/2017/9708413 contributor: fullname: Chambers – volume: 16 start-page: 1686 year: 2020 ident: B2 article-title: Long-term risk of dementia following hospitalization due to physical diseases: a multicohort study publication-title: Alzheimer's Dementia. doi: 10.1002/alz.12167 contributor: fullname: Sipilä – volume: 35 start-page: 421 year: 2017 ident: B33 article-title: Sources of inaccuracy in the measurement of adult patients' resting blood pressure in clinical settings: a systematic review publication-title: J Hypertens. doi: 10.1097/HJH.0000000000001197 contributor: fullname: Kallioinen – volume: 17 start-page: e053738 year: 2021 ident: B24 article-title: The association between long term blood pressure variability with incident dementia and cognitive impairment: a systematic review and meta-analysis publication-title: Alzheimer's Dementia. doi: 10.1002/alz.053738 contributor: fullname: Jia – volume: 189 start-page: 487 year: 2008 ident: B25 article-title: The pathway to dementia diagnosis publication-title: Med J Aust. doi: 10.5694/j.1326-5377.2008.tb02140.x contributor: fullname: Speechly – volume: 52 start-page: 2068 year: 2021 ident: B42 article-title: Autonomic imbalance and risk of dementia and stroke: the framingham study publication-title: Stroke. doi: 10.1161/STROKEAHA.120.030601 contributor: fullname: Weinstein – volume: 19 start-page: 62 year: 2018 ident: B38 article-title: Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis publication-title: BMC Neurosci. doi: 10.1186/s12868-018-0465-5 contributor: fullname: Shabir – volume: 175 start-page: 1450 year: 2015 ident: B4 article-title: Cognitive tests to detect dementia: a systematic review and meta-analysis publication-title: JAMA Intern Med. doi: 10.1001/jamainternmed.2015.2152 contributor: fullname: Tsoi – volume: 15 start-page: 66 year: 2015 ident: B1 article-title: Attitudes and preferences towards screening for dementia: a systematic review of the literature publication-title: BMC Geriatr. doi: 10.1186/s12877-015-0064-6 contributor: fullname: Martin – volume: 5 start-page: S4 year: 2013 ident: B5 article-title: Role of emerging neuroimaging modalities in patients with cognitive impairment: a review from the canadian consensus conference on the diagnosis and treatment of dementia 2012 publication-title: Alzheimer's Res Ther. doi: 10.1186/alzrt200 contributor: fullname: Burhan – volume: 62 start-page: 810 year: 2013 ident: B40 article-title: Hypertension publication-title: Hypertension. doi: 10.1161/HYPERTENSIONAHA.113.01063 contributor: fullname: Faraco – volume: 75 start-page: 982 year: 2020 ident: B15 article-title: Blood pressure variability and the risk of dementia publication-title: Hypertension. doi: 10.1161/HYPERTENSIONAHA.119.14033 contributor: fullname: Yoo – volume: 11 start-page: 5049 year: 2021 ident: B13 article-title: Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis publication-title: Sci Rep. doi: 10.1038/s41598-021-83945-z contributor: fullname: Kim – volume: 154 start-page: 781 year: 2011 ident: B34 article-title: Measuring blood pressure for decision making and quality reporting: where and how many measures? publication-title: Ann Intern Med. doi: 10.7326/0003-4819-154-12-201106210-00005 contributor: fullname: Powers – volume: 62 start-page: 727 year: 2018 ident: B20 article-title: Visit-to-visit blood pressure variability and the risk of dementia in older people publication-title: J Alzheimer's Dis. doi: 10.3233/JAD-170757 contributor: fullname: van Middelaar – volume: 15 start-page: e0235534 year: 2020 ident: B35 article-title: What older adults do with the results of dementia screening programs publication-title: PLoS ONE. doi: 10.1371/journal.pone.0235534 contributor: fullname: Galvin – volume: 10 start-page: S330 year: 2014 ident: B17 article-title: Blood pressure variability and risk of dementia in an elderly cohort, the Three-City Study publication-title: Alzheimer's Dementia. doi: 10.1016/j.jalz.2013.05.1777 contributor: fullname: Alpérovitch – volume: 16 start-page: R233 year: 2012 ident: B3 article-title: Risk factors for dementia after critical illness in elderly medicare beneficiaries publication-title: Critic Care. doi: 10.1186/cc11901 contributor: fullname: Guerra – volume: 317 start-page: 1443 year: 2017 ident: B29 article-title: Association between midlife vascular risk factors and estimated brain amyloid deposition publication-title: JAMA. doi: 10.1001/jama.2017.3090 contributor: fullname: Gottesman – volume: 5 start-page: 795 year: 2020 ident: B22 article-title: Association between visit-to-visit blood pressure variability in early adulthood and myocardial structure and function in later life publication-title: JAMA Cardiol. doi: 10.1001/jamacardio.2020.0799 contributor: fullname: Nwabuo – volume: 20 start-page: 489 year: 2020 ident: B48 article-title: Comprehensive review of ICD-9 code accuracies to measure multimorbidity in administrative data publication-title: BMC Health Serv Res. doi: 10.1186/s12913-020-05207-4 contributor: fullname: Wei – volume: 387 start-page: 2145 year: 2016 ident: B27 article-title: The World report on ageing and health: a policy framework for healthy ageing publication-title: Lancet. doi: 10.1016/S0140-6736(15)00516-4 contributor: fullname: Beard – volume: 180 start-page: 1655 year: 2020 ident: B31 article-title: Concordance between blood pressure in the systolic blood pressure intervention trial and in routine clinical practice publication-title: JAMA Intern Med. doi: 10.1001/jamainternmed.2020.5028 contributor: fullname: Drawz – volume: 1 start-page: 100 year: 2017 ident: B47 article-title: Validation of dementia coding in hospital admissions, death and primary care data publication-title: Int J Popul Data Sci. doi: 10.23889/ijpds.v1i1.100 contributor: fullname: Wilkinson – volume: 37 start-page: 605 year: 2014 ident: B36 article-title: Gender differences in coronary artery diameter are not related to body habitus or left ventricular mass publication-title: Clin Cardiol. doi: 10.1002/clc.22310 contributor: fullname: Hiteshi AK Li – volume: 23 start-page: 4962 year: 2022 ident: B8 article-title: Biomarkers for Alzheimer's disease in the current state: a narrative review publication-title: Int J Mol Sci. doi: 10.3390/ijms23094962 contributor: fullname: Gunes – volume: 20 start-page: 572 year: 2005 ident: B10 article-title: Implementing a screening and diagnosis program for dementia in primary care publication-title: J Gen Intern Med. doi: 10.1007/s11606-005-0103-7 contributor: fullname: Boustani – volume: 20 start-page: 1676 year: 2018 ident: B32 article-title: Comparison of automated clinical and research blood pressure measurements: Implications for clinical practice and trial design publication-title: J Clin Hypertens. doi: 10.1111/jch.13412 contributor: fullname: Tang – volume: 310 start-page: 118 year: 2011 ident: B44 article-title: Autonomic dysfunction in PD: a window to early detection? publication-title: J Neurol Sci. doi: 10.1016/j.jns.2011.04.011 contributor: fullname: Goldstein – volume: 18 start-page: 419 year: 2017 ident: B39 article-title: Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease publication-title: Nat Rev Neurosci. doi: 10.1038/nrn.2017.48 contributor: fullname: Kisler – volume: 16 start-page: e1002933 year: 2019 ident: B18 article-title: Variation in blood pressure and long-term risk of dementia: a population-based cohort study publication-title: PLoS Med. doi: 10.1371/journal.pmed.1002933 contributor: fullname: Ma – volume: 18 start-page: 107 year: 2020 ident: B49 article-title: Risk prediction models for dementia: role of age and cardiometabolic risk factors publication-title: BMC Med. doi: 10.1186/s12916-020-01578-x contributor: fullname: Fayosse – volume: 78 start-page: 1478 year: 2021 ident: B14 article-title: Association between blood pressure variability with dementia and cognitive impairment: a systematic review and meta-analysis publication-title: Hypertension. doi: 10.1161/HYPERTENSIONAHA.121.17797 contributor: fullname: De Heus – volume: 48 start-page: 101442 year: 2022 ident: B21 article-title: Variability independent of mean blood pressure as a real-world measure of cardiovascular risk publication-title: EClinicalMed. doi: 10.1016/j.eclinm.2022.101442 contributor: fullname: Ebinger – volume: 28 start-page: 244 year: 2019 ident: B46 article-title: The validity of dementia diagnoses in routinely collected electronic health records in the United Kingdom: a systematic review publication-title: Pharmacoepidemiol Drug Saf. doi: 10.1002/pds.4669 contributor: fullname: McGuinness – volume: 33 start-page: 1059 year: 2020 ident: B16 article-title: Blood pressure variability and dementia: a state-of-the-art review publication-title: Am J Hypertens. doi: 10.1093/ajh/hpaa119 contributor: fullname: Ma – volume: 30 start-page: 112 year: 2016 ident: B23 article-title: Visit-to-visit blood pressure variability—what is the current challenge? publication-title: Am J Hypertens. doi: 10.1093/ajh/hpw124 contributor: fullname: Yano – volume: 9 start-page: 71 year: 2017 ident: B28 article-title: Alzheimer's disease prevention: from risk factors to early intervention publication-title: Alzheimer's Research & Therapy. doi: 10.1186/s13195-017-0297-z contributor: fullname: Crous-Bou – volume: 92 start-page: e1745 year: 2019 ident: B50 article-title: Relative risk for Alzheimer disease based on complete family history publication-title: Neurology. doi: 10.1212/WNL.0000000000007231 contributor: fullname: Cannon-Albright – volume: 74 start-page: 970 year: 2017 ident: B43 article-title: Association of autonomic dysfunction with disease progression and survival in parkinson disease publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2017.1125 contributor: fullname: De Pablo-Fernandez – volume: 136 start-page: 516 year: 2017 ident: B19 article-title: Day-to-day blood pressure variability and risk of dementia in a general japanese elderly population publication-title: Circulation. doi: 10.1161/CIRCULATIONAHA.116.025667 contributor: fullname: Oishi – volume: 35 start-page: 4827 year: 2014 ident: B6 article-title: The power of neuroimaging biomarkers for screening frontotemporal dementia publication-title: Hum Brain Mapp. doi: 10.1002/hbm.22515 contributor: fullname: McMillan – volume: 322 start-page: 535 year: 2019 ident: B11 article-title: Association of midlife to late-life blood pressure patterns with incident dementia publication-title: JAMA. doi: 10.1001/jama.2019.10575 contributor: fullname: Walker – volume: 64 start-page: 256 year: 2007 ident: B45 article-title: Early development of autonomic dysfunction may predict poor prognosis in patients with multiple system atrophy publication-title: Arch Neurol. doi: 10.1001/archneur.64.2.256 contributor: fullname: Tada – volume: 12 start-page: 1282 year: 2022 ident: B7 article-title: Plasma protein biomarker model for screening Alzheimer disease using multiple reaction monitoring-mass spectrometry publication-title: Sci Rep. doi: 10.1038/s41598-022-05384-8 contributor: fullname: Kim |
SSID | ssj0000399363 |
Score | 2.3472044 |
Snippet | Recognized as a potential risk factor for Alzheimer's disease and related dementias (ADRD), blood pressure variability (BPV) could be leveraged to facilitate... Background and objectivesRecognized as a potential risk factor for Alzheimer's disease and related dementias (ADRD), blood pressure variability (BPV) could be... |
SourceID | doaj pubmedcentral proquest crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | 1085885 |
SubjectTerms | blood pressure variability dementia hospitalization hypertension Neurology risk prediction |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Na9wwEBVlD6GX0qZfbtqiQG_FXduSJfmYhoQQSE5d2JvQJ7sXb9nagf77zEje4C2FXnrxwTK2eGN7ZqQ3bwj5YmGgErYpYx1syV3tS2ViW9aN9FFJ1yqT2Bb34mbFb9ftetbqCzlhWR44A7cMlXWmca3pbMONjHCEu7YBIgcno8rZetXMkqn0D0a_K1iukoEsrFtG1If8hs3CkVbXKmyePPNESbD_b1Hmn2TJmfe5fkleTGEjvcjTfUWehf6UnNxNG-OviZnBTHeRJj46TSTXcR_oA2TEWZD7N82FidS4cQgUiV90M_UOmUoyqek9xSV4rOGlPq0fbs0bsrq--nF5U07dE0rH624oO2u4ZZCfmBCF8Lb2bbQR4GxlcB1EEVx6FIdhMKaiAz_uRRd9YLKJ0XrL3pJFv-vDe0IDRIHwbSvFa8crw6wSoYqGcWmFlIYX5OsBSf0zi2RoSC4Qd51w14i7nnAvyHcE--lKFLhOJ8DsejK7_pfZC3J-MJWGDwJ3OUwfduMv3UiFLpgLVpB32XRPj2JCNdhzrSDyyKhHczke6bebJLrddZjqyg__Y_Jn5DkCksjf8iNZDPsxfILYZrCf02v8CFCL_Oo priority: 102 providerName: Directory of Open Access Journals – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9wwEB7SFEovoe86faBCb8WpH3r5UEpbGkIhPXUhN6FnEwjeZrMbkn-fGVkbsiU99GKwZWx5RvLMSN_MB_DeYUMjXVenNrqa-zbU2iZRt50KSSsvtM1oi5_yYMZ_HImjLVjTHRUBnt8Z2hGf1Gxxund5dvUZJ_wnijjR3n5MVPpxj3jACTEntBb34H6HlpEgXofF3c9_ZrLGmVytlZLXxGQ95dH84zEbtiqX9L_LD_0bTnnLPu0_gp3iWLIv00h4DFtxfAIPDsvW-VOwtxTB5ollxDrLMNjVIrILjJmnkt1XbEpdZNavlpERNIwdF3aRkrTJ7BgYLdJTli8LeYXxxD6D2f73X98O6sKvUHveDst6cJa7HiMYG5OUwbVBJJdi44SKfkA_g6tA5WN6bNPJo6UPckgh9qpLyQXXP4ftcT7Gl8Ai-ok4-7XmreeN7Z2WsUm258pJpSyv4MNakubPVEbDYPhBcjdZ7obkborcK_hKwr65k0pg5wvzxW9TZpTBfnrbeWEH13GrEh5xuImILqVXSTcVvFuryuCUoX0QO8b56tx0SpOR5rKv4MWkuptX9VJ3xMpWgdpQ6kZfNlvGk-NclnsYKBhWu__1qa_gIZ1mHLh6DdvLxSq-QTdn6d7msXsNOjP93g priority: 102 providerName: Scholars Portal |
Title | Association of blood pressure variability during acute care hospitalization and incident dementia |
URI | https://www.ncbi.nlm.nih.gov/pubmed/36824417 https://search.proquest.com/docview/2780067463 https://pubmed.ncbi.nlm.nih.gov/PMC9941567 https://doaj.org/article/e0bca2c5a9b24a7fb241eb5e835c7f80 |
Volume | 14 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Li9RAEC529yBexLfxsbTgTTKTpJ856uKyCCMeXNhb0093wM0s44zgv7eqk1lmxJOXHNIJab6qTlV1f1UF8M7jQKN8V-c2-VqENtbGZVm3nY7Z6CCNK2yLL-riUny-kldHIHe5MIW0H_xyNvy4mQ3L68KtvL0J8x1PbP51cdb3FHbo-TEco_ndC9HL75dMruJjggwGYP08U2nIGfUJJ0adNNQ3ec8IlVr9_3Iw_-ZJ7hme84fwYPIY2YdxZo_gKA2P4d5iOhN_Am4PYbbKrFDRWeG3bteJ_cJgeKzF_ZuNOYnMhe0mMeJ8seupbciUjcncEBntvlP6Lotl63DpnsLl-advZxf11DihDqLtN3XvnfAcQxOXslLRt1Fmn1PjpU6hRwdC6Eh1YTiOmRzQhEfV55i47nL20fNncDKshvQCWEIHEJe1MaINonHcG5Wa7LjQXmntRAXvd0ja27E-hsW4gnC3BXdLuNsJ9wo-Eth3T1Jt63Jjtf5uJwlbnGdwXZCu951wOuMV9Ugm9BWDzqap4O1OVBbXAh1wuCGttj9tpw1ZX6F4Bc9H0d19iivTUbu1CvSBUA_mcjiC6lfqbU_q9vK_33wF9wmFQvbWr-Fks96mN-jLbPxp2QPA60KY06LHfwCY1Px1 |
link.rule.ids | 230,314,727,780,784,864,885,2102,24318,27924,27925,53791,53793 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB6VIgGXijdueSwSN-TE9j59LBVVgKbi0Eq9rfbZRqJOlSaV-PfsrJ0qQZy4-OC15dU3s56Z3W9mAD7ZNFAJ25SxDrZkrvalMpGXdSN9VNJxZTLb4lRMztn3C36xA3ydC5NJ-87ORt2v61E3u8rcyptrN17zxMY_p0dti2GHHD-Ah5zKtt4I0vMPGI2uoH2KTArB2nHE4pAj7BSOnDqusHPyhhnK1fr_5WL-zZTcMD3HT2Fv8BnJYT-3Z7ATuufwaDqcir8As4ExmUeSyegkM1xXi0DuUjjcV-P-TfqsRGLcahkIsr7I1dA4ZMjHJKbzBPffMYGX-Lx5ODMv4fz469nRpBxaJ5SO1e2ybK1hlqbgxIQohLe159HGUFkug2uTC8Gkx8owNI2p6JIR96KNPlDZxGi9pa9gt5t34Q2QkFzAtLCVYrVjlaFWiVBFQ5m0QkrDCvi8RlLf9BUydIosEHedcdeIux5wL-ALgn3_JFa3zjfmi0s9yFineTrTOG5a2zAjY7omTeIheYtORlUV8HEtKp1WAx5xmC7MV7e6kQrtLxO0gNe96O4_RYVqsOFaAXJLqFtz2R5JCpgrbg8Kt__fb36Ax5Oz6Yk--Xb64wCeICKZ-i3fwu5ysQrvkmeztO-zHv8BHTX9-w |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5BkSouiDfhaSRuKJuHnzlCYVUerXqgUm-Wn3Qlml0tu0j8ezxOtsoiTlxyiBPF-macmbG_mQF4Y9NALWxbxibYkrnGl8pEXjat9FFJx5XJbItTcXzOPl_wi0mrr0zad3Yx639czfrFZeZWrq5cteOJVWcnR12HYYesVj5WN-EWp0nJJoF6_gmj4RV0SJNJYVhXRSwQOcNu4cir4wq7J09MUa7Y_y8382-25MT8zO_CndFvJO-G-d2DG6G_D4cn48n4AzATnMkykkxIJ5nlul0H8iuFxENF7t9kyEwkxm03gSDzi1yOzUPGnExiek9wDx6TeInPG4gL8xDO5x-_HR2XY_uE0rGm25SdNczSFKCYEIXwtvE82hhqy2VwXXIjmPRYHYamMRVdMuRedNEHKtsYrbf0ERz0yz48ARKSG5gWt1Kscaw21CoR6mgok1ZIaVgBb3dI6tVQJUOn6AJx1xl3jbjrEfcC3iPY109ihet8Y7n-rkc56zRPZ1rHTWdbZmRM16RNPCSP0cmo6gJe70Sl04rAYw7Th-X2p26lQhvMBC3g8SC6609RoVpsulaA3BPq3lz2R5IS5qrbo9I9_e83X8Hh2Ye5_vrp9MszuI2AZPa3fA4Hm_U2vEjOzca-zGr8B6u7_w4 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+of+blood+pressure+variability+during+acute+care+hospitalization+and+incident+dementia&rft.jtitle=Frontiers+in+neurology&rft.au=Ebinger%2C+Joseph+E.&rft.au=Driver%2C+Matthew+P.&rft.au=Botting%2C+Patrick&rft.au=Wang%2C+Minhao&rft.date=2023-02-07&rft.issn=1664-2295&rft.eissn=1664-2295&rft.volume=14&rft_id=info:doi/10.3389%2Ffneur.2023.1085885&rft.externalDBID=n%2Fa&rft.externalDocID=10_3389_fneur_2023_1085885 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-2295&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-2295&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-2295&client=summon |