Fibroblast Growth Factor 1 Gene and Hypertension From the Quantitative Trait Locus to Positional Analysis

• Published in: Circulation (New York, N.Y.) Vol. 116; no. 17; pp. 1915 - 1924
• Main Authors: Tomaszewski, Maciej, Charchar, Fadi J., Lynch, Mark D., Padmanabhan, Sandosh, Wang, William Y.S., Miller, William H., Grzeszczak, Wladyslaw, Maric, Christine, Zukowska-Szczechowska, Ewa, Dominiczak, Anna F.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 23.10.2007
• Subjects: Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - genetics; Blood vessels and receptors; Cardiology. Vascular system; Chromosome Mapping; Chromosomes, Human, Pair 5 - genetics; Chromosomes, Human, Pair 5 - metabolism; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Family; Female; Fibroblast Growth Factor 1 - biosynthesis; Fibroblast Growth Factor 1 - genetics; Fundamental and applied biological sciences. Psychology; Hormones. Endocrine system; Humans; Hypertension - genetics; Hypertension - metabolism; Linkage Disequilibrium; Male; Medical sciences; Mesangial Cells - metabolism; Middle Aged; Pharmacology. Drug treatments; Poland; Polymorphism, Single Nucleotide; Quantitative Trait Loci - genetics; Up-Regulation - genetics; Vertebrates: cardiovascular system; Poland; Hypertension; Fibroblast growth factor; kidney; genetics; growth substances; Cardiovascular disease; Locus; Growth substance

Background— The distal portion of the long arm of chromosome 5 is linked to hypertension and contains functional candidate blood pressure–regulating genes. Methods and Results— Tightening the grid of microsatellite markers under this quantitative trait locus in the Silesian Hypertension Study (629 i...