Pristimerin isolated from Salacia crassifolia (Mart. Ex. Schult.) G. Don. (Celastraceae) roots as a potential antibacterial agent against Staphylococcus aureus

• Published in: Journal of ethnopharmacology Vol. 266; no. NA; p. 113423
• Main Authors: Nizer, Waleska Stephanie da Cruz, Ferraz, Ariane Coelho, Moraes, Thaís de Fátima Silva, Lima, William Gustavo, Santos, Josana Pereira dos, Duarte, Lucienir Pains, Ferreira, Jaqueline Maria Siqueira, de Brito Magalhães, Cintia Lopes, Vieira-Filho, Sidney Augusto, Andrade, Ana Claúdia dos Santos Pereira, Rodrigues, Rodrigo Araújo Lima, Abrahão, Jonatas Santos, Magalhães, José Carlos de
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.02.2021
• Subjects: Animals; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Anti-staphylococcal; Antibacterial activity; antibacterial properties; antibiotics; biofilm; Biofilms - drug effects; Chlorocebus aethiops; computer simulation; computer software; cytotoxicity; dose response; gentian violet; Gram-Positive Bacteria - drug effects; hexane; mechanism of action; membrane permeability; Microbial Sensitivity Tests; minimum inhibitory concentration; Plant Roots; Pristimerin; S. aureus biofilm; Salacia; Salacia - chemistry; Salacia crassifolia; Staphylococcal Infections - drug therapy; Staphylococcus aureus; Staphylococcus aureus - drug effects; Synergic effect; synergism; traditional medicine; transmission electron microscopy; Triterpenes - isolation & purification; Triterpenes - pharmacology; triterpenoids; Vero Cells; CLSI; FIC; CI; MIC; FICI; Pristimerin; Anti-staphylococcal; MTT; ATCC; MBC; S. aureus biofilm; HER; PASS; ANOVA; OD; SI; Synergic effect; MRSA; Salacia crassifolia; Antibacterial activity; MH; TEM; WHO

Pristimerin is a triterpenoid considered the main component of Salacia crassifolia extracts. This terpene has shown promising antitumor, anti-inflammatory, and antimicrobial effects. Likewise, S. crassifolia has been used in traditional medicine to treat cancer and as an antimicrobial and anti-infla...