Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

• Published in: Biochemical journal Vol. 453; no. 1; p. 137
• Main Authors: Tatham, Michael H, Plechanovová, Anna, Jaffray, Ellis G, Salmen, Helena, Hay, Ronald T
• Format: Journal Article
• Language: English
• Published: England 01.07.2013
• Subjects: Nuclear Proteins - metabolism; Small Ubiquitin-Related Modifier Proteins - metabolism; Transcription Factors - metabolism; Ubiquitin - metabolism; Ubiquitin-Conjugating Enzymes - metabolism; Ubiquitin-Protein Ligases - metabolism; Ubiquitination

The covalent attachment of the protein ubiquitin to intracellular proteins by a process known as ubiquitylation regulates almost all major cellular systems, predominantly by regulating protein turnover. Ubiquitylation requires the co-ordinated action of three enzymes termed E1, E2 and E3, and typica...