TOX3 deficiency mitigates hyperglycemia by suppressing hepatic gluconeogenesis through FoxO1

• Published in: Metabolism, clinical and experimental Vol. 152; p. 155766
• Main Authors: Liu, Congcong, Zheng, Yuanwen, Hu, Shourui, Liang, Xiaofan, Li, Yuxuan, Yu, Zhiheng, Liu, Yue, Bian, Yuehong, Man, Yuanyuan, Zhao, Shigang, Liu, Xin, Liu, Hongbin, Huang, Tao, Ma, Jinlong, Chen, Zi-Jiang, Zhao, Han, Zhang, Yuqing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2024
• Subjects: Animals; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Forkhead Box Protein O1 - genetics; Forkhead Box Protein O1 - metabolism; FoxO1; Gluconeogenesis; Gluconeogenesis - genetics; Glucose - metabolism; Humans; Hyperglycemia; Hyperglycemia - genetics; Hyperglycemia - metabolism; Insulin Resistance; Liver - metabolism; Mice; Mice, Inbred C57BL; TOX3; Type 2 diabetes; Type 2 diabetes; TOX3; Hyperglycemia; Gluconeogenesis; FoxO1

Excessive hepatic glucose production is a hallmark that contributes to hyperglycemia in type 2 diabetes (T2D). The regulatory network governing this process remains incompletely understood. Here, we demonstrate that TOX3, a high-mobility group family member, acts as a major transcriptional driver fo...