Synthesis, copolymerization and peptide-modification of carboxylic acid-functionalized 3,4-ethylenedioxythiophene (EDOTacid) for neural electrode interfaces

• Published in: Biochimica et biophysica acta Vol. 1830; no. 9; pp. 4288 - 4293
• Main Authors: Povlich, Laura K., Cho, Jae Cheol, Leach, Michelle K., Corey, Joseph M., Kim, Jinsang, Martin, David C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2013
• Subjects: Adhesion; Animals; bioactive properties; Biocompatible Materials - chemical synthesis; Biocompatible Materials - chemistry; Biomaterial; Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis; Bridged Bicyclo Compounds, Heterocyclic - chemistry; Carboxylic Acids - chemical synthesis; Carboxylic Acids - chemistry; Cells, Cultured; composite polymers; Conjugated polymer; Electrochemical; electrodes; Electrodes, Implanted; medicine; motor neurons; Motor Neurons - physiology; Neuron; peptides; Peptides - chemistry; Polymerization; Polymers - chemical synthesis; Polymers - chemistry; prostheses; Rats; RGD; Conjugated polymer; Biomaterial; Neuron; Adhesion; RGD; Electrochemical

Conjugated polymers have been developed as effective materials for interfacing prosthetic device electrodes with neural tissue. Recent focus has been on the development of conjugated polymers that contain biological components in order to improve the tissue response upon implantation of these electr...