Honokiol induces cell cycle arrest and apoptosis via inhibition of survival signals in adult T-cell leukemia - Ishikawa, Chie; Arbiser, Jack L.; Mori, Naoki (Biochimica et biophysica acta, 2012)
Keywords: Adult; Adult T-cell leukemia; adults; Animals; Antineoplastic Agents, Phytogenic - pharmacology; apoptosis; Apoptosis - drug effects; biphenyl; Biphenyl Compounds - pharmacology; Blotting, Western; caspases; cell cycle checkpoints; Cell Cycle Checkpoints - drug effects; cell growth; Cell Line, Tumor; Cell Proliferation - drug effects; Cell survival; Cell Survival - drug effects; cell viability; colorimetry; cyclin-dependent kinase; cyclins; cytotoxicity; DNA; Electrophoretic Mobility Shift Assay; Female; gene expression regulation; Honokiol; Human T-cell leukemia virus type 1; Humans; IKappaB kinase; leukemia; Leukemia-Lymphoma, Adult T-Cell - drug therapy; Leukemia-Lymphoma, Adult T-Cell - metabolism; Leukemia-Lymphoma, Adult T-Cell - pathology; Lignans - pharmacology; Mice; Mice, Inbred ICR; Mice, SCID; NF-kappa B - genetics; NF-kappa B - metabolism; phosphorylation; Primate T-lymphotropic virus 1; pro-apoptotic proteins; propidium; Signal Transduction - drug effects; Signaling; T-lymphocytes; transcription factor NF-kappa B; Tumor Cells, Cultured; viruses; Western blotting; Honokiol; Human T-cell leukemia virus type 1; Signaling; Adult T-cell leukemia; Cell survival