In vivo direct relation of tau pathology with neuroinflammation in early Alzheimer’s disease

• Published in: Journal of neurology Vol. 266; no. 9; pp. 2186 - 2196
• Main Authors: Terada, Tatsuhiro, Yokokura, Masamichi, Obi, Tomokazu, Bunai, Tomoyasu, Yoshikawa, Etsuji, Ando, Ichiro, Shimada, Hitoshi, Suhara, Tetsuya, Higuchi, Makoto, Ouchi, Yasuomi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2019; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Alzheimer Disease - psychology; Alzheimer's disease; Brain - diagnostic imaging; Brain - metabolism; Cognitive ability; Cross-Sectional Studies; Female; Humans; Inflammation; Inflammation - diagnostic imaging; Inflammation - metabolism; Inflammation - psychology; Male; Medicine; Medicine & Public Health; Middle Aged; Neurology; Neuropsychological Tests; Neuroradiology; Neurosciences; Original Communication; Parahippocampal gyrus; Positron emission tomography; Positron-Emission Tomography - trends; Tau protein; tau Proteins - metabolism; TAU; [; Alzheimer’s disease; C]PBB3; Positron emission tomography; Microglia; [11C]PBB3

Objective Neuronal damage and neuroinflammation are important events occurring in the brain of Alzheimer’s disease (AD). The purpose of this study was to clarify in vivo mutual relationships among abnormal tau deposition, neuroinflammation and cognitive impairment in patients with early AD using pos...