Computational models for lncRNA function prediction and functional similarity calculation

• Published in: Briefings in functional genomics Vol. 18; no. 1; pp. 58 - 82
• Main Authors: Chen, Xing, Sun, Ya-Zhou, Guan, Na-Na, Qu, Jia, Huang, Zhi-An, Zhu, Ze-Xuan, Li, Jian-Qiang
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 14.02.2019
• Subjects: Algorithms; biomarkers; Computational Biology - methods; Computer Simulation; Disease - genetics; Gene Regulatory Networks; genomics; Humans; nervous system; non-coding RNA; prediction; prognosis; RNA, Long Noncoding - genetics; therapeutics; transcription (genetics); computational model; functional similarity calculation; database; long non-coding RNA; disease; function prediction

Abstract From transcriptional noise to dark matter of biology, the rapidly changing view of long non-coding RNA (lncRNA) leads to deep understanding of human complex diseases induced by abnormal expression of lncRNAs. There is urgent need to discern potential functional roles of lncRNAs for further...