Human threat circuits: Threats of pain, aggressive conspecific, and predator elicit distinct BOLD activations in the amygdala and hypothalamus

• Published in: Frontiers in psychiatry Vol. 13; p. 1063238
• Main Authors: Bertram, Teresa, Hoffmann Ayala, Daniel, Huber, Maria, Brandl, Felix, Starke, Georg, Sorg, Christian, Mulej Bratec, Satja
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.01.2023
• Subjects: fMRI; human; Psychiatry; threat conditioning; threat responses; threat types; translational neuroscience; fMRI; threat conditioning; threat circuit; threat types; threat responses; human; translational neuroscience

Threat processing, enabled by threat circuits, is supported by a remarkably conserved neural architecture across mammals. Threatening stimuli relevant for most species include the threat of being attacked by a predator or an aggressive conspecific and the threat of pain. Extensive studies in rodents...