Bioelectronics meets nanomedicine for cardiovascular implants: PEDOT-based nanocoatings for tissue regeneration

• Published in: Biochimica et biophysica acta Vol. 1830; no. 9; pp. 4294 - 4304
• Main Authors: Karagkiozaki, V., Karagiannidis, P.G., Gioti, M., Kavatzikidou, P., Georgiou, D., Georgaraki, E., Logothetidis, S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2013
• Subjects: adsorption; Atomic Force Microscopy; Bioelectronics; Bridged Bicyclo Compounds, Heterocyclic - chemistry; Cardiovascular System - drug effects; cell adhesion; Cell Adhesion - drug effects; cell proliferation; Cell Proliferation - drug effects; Cell Survival - drug effects; cell viability; Cells, Cultured; chemical bonding; coatings; Conductive polymer; drugs; Electronics, Medical - instrumentation; Electronics, Medical - methods; fibroblasts; Fibroblasts - drug effects; human serum albumin; Humans; hydrophilicity; Hydrophobic and Hydrophilic Interactions; immune response; Microscopy, Atomic Force - methods; nanomaterials; Nanomedicine; Nanomedicine - instrumentation; PEDOT; peptides; polymerization; polymers; Polymers - chemistry; Prostheses and Implants; Regeneration - physiology; scanning electron microscopy; Serum Albumin - metabolism; spectroscopy; Spectrum Analysis - methods; Stent; thrombosis; tissue repair; vapors; wettability; Wettability - drug effects; PBS; RT; DMSO; Ry; AFM; DL; Bioelectronics; Atomic Force Microscopy; NGF; Stent; RGD; PSS; SE; DES; PEDOT; PEG; VPP; TL; TOS; Conductive polymer; SEM; Nanomedicine; Rq

An exciting direction in nanomedicine would be to analyze how living cells respond to conducting polymers. Their application for tissue regeneration may advance the performance of drug eluting stents by addressing the delayed stent re-endothelialization and late stent thrombosis. The suitability of...