Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 13; no. 6; pp. 591 - 599
• Main Authors: Raychaudhuri, Baisakhi, Rayman, Patricia, Ireland, Joanna, Ko, Jennifer, Rini, Brian, Borden, Ernest C., Garcia, Jorge, Vogelbaum, Michael A., Finke, James
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.2011
• Subjects: Arginase - metabolism; Basic and Translational Investigations; Brain Neoplasms - blood; Brain Neoplasms - diagnosis; Brain Neoplasms - immunology; Case-Control Studies; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glioblastoma - blood; Glioblastoma - diagnosis; Glioblastoma - immunology; Granulocyte Colony-Stimulating Factor - metabolism; Humans; Interferon-gamma - metabolism; Leukocytes, Mononuclear - immunology; Lymphocyte Activation; Middle Aged; Myeloid Cells - immunology; Myeloid Cells - pathology; T-Lymphocytes - immunology; Arginase; GBM; MDSC; G-CSF; neutrophil

To assess the accumulation of myeloid-derived suppressor cells (MDSCs) in the peripheral blood of patients with glioma and to define their heterogeneity and their immunosuppressive function. Peripheral blood mononuclear cells (PBMCs) from healthy control subjects and from patients with newly diagnos...